Yang Yu, Li Yuxuan, Du Xiaohui
Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, China.
Gastroenterol Res Pract. 2021 Jan 25;2021:9204373. doi: 10.1155/2021/9204373. eCollection 2021.
To identify and evaluate the influence of intraperitoneal chemotherapy without hyperthermia (IC) to the incidence of anastomotic leakage (AL) after colorectal cancer surgery.
A systematic review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses in order to review all studies investigating the relationship between IC and AL in patients undergoing colorectal surgery. The primary outcome was overall incidence rate of anastomotic leakage.
Four studies were included in the final review. IC was associated with an overall increased risk of anastomotic leakage [OR 2.05 (1.06, 3.98), = 0.03]. But there was no significant increased incidence rate when fluorouracil was implanted into the abdominal cavity for IC [OR 2.48 (0.55, 11.10), = 0.24].
This meta-analysis provides some evidence to suggest IC may increase the incidence of postoperative AL in colorectal cancer. However, fluorouracil implantation for IC does not increase the risk of AL, which seems to be a relatively safe method of IC.
确定并评估非热灌注腹腔内化疗（IC）对结直肠癌手术后吻合口漏（AL）发生率的影响。
根据系统评价和Meta分析的首选报告项目进行系统评价和Meta分析，以回顾所有调查结直肠手术患者IC与AL之间关系的研究。主要结局是吻合口漏的总体发生率。
最终评价纳入四项研究。IC与吻合口漏总体风险增加相关[比值比（OR）2.05（1.06，3.98），P = 0.03]。但腹腔内植入氟尿嘧啶进行IC时，发生率无显著增加[OR 2.48（0.55，11.10），P = 0.24]。
这项Meta分析提供了一些证据表明IC可能增加结直肠癌术后AL的发生率。然而，腹腔内植入氟尿嘧啶进行IC不会增加AL的风险，这似乎是一种相对安全的IC方法。
