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海德综合征的医学管理。

Medical Management of Heyde Syndrome.

作者信息

Sinha Samridhi, Castro Daniel, Shakil Shams

机构信息

Internal Medicine, The Brooklyn Hospital Center/Mount Sinai Heart, Brooklyn, USA.

Hemotolgy and Oncology, The Brooklyn Hospital Center/Mount Sinai Heart, Brooklyn, USA.

出版信息

Cureus. 2021 Jan 7;13(1):e12551. doi: 10.7759/cureus.12551.

DOI:10.7759/cureus.12551
PMID:33564544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7863051/
Abstract

Heyde syndrome is a triad of bleeding colonic angiodysplasia, aortic stenosis, and acquired coagulopathy. It is most commonly seen in the elderly between 60-80 years of age. We present a case of Heyde syndrome presenting with severe anemia secondary to bleeding angiodysplasia or arteriovenous malformations (AVM) in the lower gastrointestinal (GI) tract.

摘要

海德综合征是一种由结肠血管发育异常出血、主动脉瓣狭窄和获得性凝血病组成的三联征。它最常见于60至80岁的老年人。我们报告一例海德综合征病例，该病例因下消化道血管发育异常出血或动静脉畸形导致严重贫血。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea43/7863051/4cbb45ece2e9/cureus-0013-00000012551-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea43/7863051/c7a4c8726762/cureus-0013-00000012551-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea43/7863051/4cbb45ece2e9/cureus-0013-00000012551-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea43/7863051/c7a4c8726762/cureus-0013-00000012551-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea43/7863051/4cbb45ece2e9/cureus-0013-00000012551-i02.jpg

相似文献

1
Medical Management of Heyde Syndrome.海德综合征的医学管理。
Cureus. 2021 Jan 7;13(1):e12551. doi: 10.7759/cureus.12551.
2
A Case of Heyde Syndrome with Resolution of Gastrointestinal Bleeding Two Weeks After Aortic Valve Replacement.主动脉瓣置换术后两周胃肠道出血缓解的黑德综合征病例。
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Aortic Valve Stenosis, a Precipitating Factor of Recurrent Bleed in Colonic Angiodysplasia: A Literature Review.主动脉瓣狭窄——结肠血管发育异常反复出血的一个促发因素：文献综述
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J Nippon Med Sch. 2017;84(4):193-197. doi: 10.1272/jnms.84.193.
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Refractory Iron-Deficiency Anemia and Vascular Malformation Concomitant with Aortic Stenosis: Heyde Syndrome.难治性缺铁性贫血伴发主动脉瓣狭窄的血管畸形：海德尔综合征。
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A surgical case of aortic stenosis with recurrent gastrointestinal bleeding: Heyde syndrome.一例主动脉瓣狭窄合并反复胃肠道出血的外科病例：海德综合征。
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Heyde Syndrome: An Unusual Cause of Gastrointestinal Bleeding.海德综合征：胃肠道出血的一个不常见病因。
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Aortic Stenosis Complicated by Gastrointestinal Arteriovenous Malformations: It is not Always Heyde Syndrome.合并胃肠道动静脉畸形的主动脉瓣狭窄：并非总是黑德综合征。
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Heyde syndrome: a common diagnosis in older patients with severe aortic stenosis.海德综合征：老年重度主动脉瓣狭窄患者的常见诊断。
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引用本文的文献

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Gastric Antral Vascular Ectasia Syndrome With Aortic Stenosis: A Twist on Heyde Syndrome?胃窦血管扩张综合征合并主动脉瓣狭窄：黑德综合征的一种变体？
J Med Cases. 2025 Jan;16(1):17-22. doi: 10.14740/jmc4311. Epub 2024 Dec 21.
2
Heyde's syndrome: a systematic review of case reports.海迪综合征：病例报告的系统评价。
BMJ Open Gastroenterol. 2022 May;9(1). doi: 10.1136/bmjgast-2021-000866.

本文引用的文献

1
Heyde syndrome: gastrointestinal bleeding and aortic stenosis.海德综合征：胃肠道出血与主动脉瓣狭窄。
CMAJ. 2016 Feb 2;188(2):135-138. doi: 10.1503/cmaj.150194. Epub 2015 Jun 29.
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From clinical observation to mechanism--Heyde's syndrome.从临床观察到发病机制——海德氏综合征
N Engl J Med. 2012 Nov 15;367(20):1954-6. doi: 10.1056/NEJMcibr1205363.
3
Loss of high-molecular-weight von Willebrand factor multimers mainly affects platelet aggregation in patients with aortic stenosis.在主动脉瓣狭窄患者中，高分子量 von Willebrand 因子多聚体的丢失主要影响血小板聚集。
Thromb Haemost. 2010 Feb;103(2):408-14. doi: 10.1160/TH09-06-0391. Epub 2009 Dec 18.
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Heyde syndrome: a common diagnosis in older patients with severe aortic stenosis.海德综合征：老年重度主动脉瓣狭窄患者的常见诊断。
Age Ageing. 2009 May;38(3):267-70; discussion 251. doi: 10.1093/ageing/afp019. Epub 2009 Mar 10.
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Heyde's syndrome: a review.海德氏综合征：综述
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Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome.胃肠道出血、血管发育异常、心血管疾病和获得性血管性血友病综合征。
Transfus Med Rev. 2003 Oct;17(4):272-86. doi: 10.1016/s0887-7963(03)00037-3.
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Shear stress enhances the proteolysis of von Willebrand factor in normal plasma.切应力可增强正常血浆中血管性血友病因子的蛋白水解作用。
Blood. 1994 Apr 15;83(8):2171-9.
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Idiopathic gastrointestinal bleeding and aortic stenosis.特发性胃肠道出血与主动脉瓣狭窄
Am J Dig Dis. 1974 May;19(5):393-8. doi: 10.1007/BF01255601.
9
Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation.剪切应力诱导血管性血友病因子与血小板糖蛋白Ib结合，引发与聚集相关的钙内流。
Blood. 1992 Jul 1;80(1):113-20.
10
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link?主动脉瓣狭窄与胃肠道血管发育异常出血：获得性血管性血友病是其中的关联吗？
Lancet. 1992 Jul 4;340(8810):35-7. doi: 10.1016/0140-6736(92)92434-h.