Qasim Abdallah, Kousa Omar, Andukuri Venkata Giri
Department of Internal Medicine, Creighton University, Nebraska, United States.
J Clin Transl Res. 2020 Dec 11;6(6):198-202.
Hypolipidemia, an increasingly diagnosed disorder, is defined as a low-density lipoprotein serum level of <50 mg/dL. Hypolipidemia can be asymptomatic. However, the effect of hypolipidemia on sepsis survival and severity is still to be identified. Multiple studies show the physiologic effects of cholesterol on the immune system, and other studies linked hypolipidemia to increased mortality and morbidity. In this case, we present a young patient admitted for severe sepsis, and he developed multiorgan failure. Workup revealed hypolipidemia. The patient recovered from sepsis with residual renal and cardiac injury. We hypothesized that hypolipidemia could be contributing to the increased morbidity in the patient, although further studies are needed to approve this hypothesis. What is unique about this case is that it sheds light on a commonly overlooked metabolic abnormality that plays a role in the body's response to infections and sepsis.
This case report presents a previously healthy young patient admitted for pneumonia who had a complicated course. Workup revealed hypolipidemia that can be contributing to the severity of his disease. This observation may lead to more studies to evaluate the relationship between lipoprotein level and disease severity which may change the management for patients with hypolipidemia, especially with the familial type.
低脂血症是一种诊断日益增多的病症，定义为血清低密度脂蛋白水平<50mg/dL。低脂血症可能无症状。然而，低脂血症对脓毒症存活和严重程度的影响仍有待确定。多项研究显示了胆固醇对免疫系统的生理作用，其他研究则将低脂血症与死亡率和发病率增加联系起来。在此病例中，我们介绍了一名因严重脓毒症入院的年轻患者，他出现了多器官功能衰竭。检查发现有低脂血症。该患者从脓毒症中康复，但遗留有肾脏和心脏损伤。我们推测低脂血症可能导致了该患者发病率增加，不过还需要进一步研究来证实这一假设。此病例的独特之处在于它揭示了一种常被忽视的代谢异常，这种异常在机体对感染和脓毒症的反应中起作用。
本病例报告介绍了一名因肺炎入院的既往健康年轻患者，其病程复杂。检查发现低脂血症可能导致了其病情的严重程度。这一观察结果可能会促使更多研究来评估脂蛋白水平与疾病严重程度之间的关系，这可能会改变对低脂血症患者的治疗，尤其是家族性类型的患者。
