Clinical Neurosciences, University of Turku, Turku, Finland.
Neurocenter, Turku University Hospital, Turku, Finland.
Ann Neurol. 2021 May;89(5):1046-1050. doi: 10.1002/ana.26046. Epub 2021 Mar 3.
Parkinson's disease and other Lewy body spectrum diseases (LBDs) are associated with a specific risk for clinical depression. In the present clinicopathological study with 73 patients with LBD, we observed that the substantia nigra pars compacta dopamine neuron density was markedly lower in patients who had comorbid depression antemortem than in nondepressed patients (1.52 vs 2.32 n/mm , p = 0.004). There were no differences in cognition, motor disease severity, antiparkinsonian medications, or disease duration between groups. The results implicate the substantia nigra as an important psychomotor modulatory area of mood in patients with Lewy body disorders. ANN NEUROL 2021;;89:1046-1050.
帕金森病和其他路易体谱系疾病（LBD）与临床抑郁症有特定的风险相关。在这项涉及 73 例 LBD 患者的临床病理研究中，我们观察到，生前合并抑郁症的患者黑质致密部多巴胺神经元密度明显低于无抑郁症患者（1.52 比 2.32 n/mm ，p = 0.004）。两组间在认知、运动疾病严重程度、抗帕金森病药物或疾病持续时间方面均无差异。结果提示，黑质可能是路易体障碍患者情绪的重要精神运动调节区域。神经病学年鉴 2021 ；89：1046-1050。
