急性胰腺炎后胰腺外分泌功能不全：一项前瞻性、观察性、多中心队列研究的原理和方法。
Post-Acute Pancreatitis Pancreatic Exocrine Insufficiency: Rationale and Methodology of a Prospective, Observational, Multicenter Cohort Study.
机构信息
From the Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
Department of Gastroenterology, Mayo Clinic Heath System, Eau Claire, WI.
出版信息
Pancreas. 2021 Feb 1;50(2):147-152. doi: 10.1097/MPA.0000000000001743.
OBJECTIVES
We describe the methodology of Post-Acute Pancreatitis Pancreatic Exocrine Insufficiency (PAPPEI), a prospective, observational, multicenter cohort study. The objectives of PAPPEI are to estimate the incidence rate of post-acute pancreatitis (AP) pancreatic exocrine insufficiency (PEI), define factors that determine the development of post-AP PEI, and evaluate the impact of post-AP PEI on nutritional status and quality of life.
METHODS
Enrollment started in June 2017 in 3 expert academic centers in the United States. Data were collected during hospitalization (baseline) at 3 and 12 months after enrollment. Fecal elastase-1 was used to assess PEI. Study questionnaires are completed by patient interview and review of electronic medical records. Blood is obtained to evaluate vitamin deficiencies and nutritional markers.
RESULTS
As of August 2020, 77 subjects have completed the baseline evaluation. The median age was 58 years (interquartile range, 39-67 years), 38% were male, and 90% were white. The etiology of AP was biliary in 39 subjects (51%), and 51 subjects (66%) had mild AP. Three- and 12-month follow-up data have been collected in 29 and 13 subjects, respectively.
CONCLUSION
The PAPPEI study aims to expand our understanding of post-AP PEI incidence, including its impact on nutritional status and quality of life.
目的
我们描述了急性胰腺炎后胰腺外分泌功能不全（PAPPEI）的研究方法，这是一项前瞻性、观察性、多中心队列研究。PAPPEI 的目的是估计急性胰腺炎（AP）后胰腺外分泌功能不全（PEI）的发生率，确定决定 AP 后 PEI 发展的因素，并评估 AP 后 PEI 对营养状况和生活质量的影响。
方法
该研究于 2017 年 6 月在美国 3 个学术中心开始入组。在入组后 3 个月和 12 个月时收集住院期间（基线）的数据。粪便弹性蛋白酶-1 用于评估 PEI。通过患者访谈和电子病历回顾完成研究问卷。采集血液以评估维生素缺乏和营养标志物。
结果
截至 2020 年 8 月，已有 77 例患者完成了基线评估。中位年龄为 58 岁（四分位间距，39-67 岁），38%为男性，90%为白人。AP 的病因在 39 例（51%）为胆源性，51 例（66%）为轻度 AP。分别有 29 例和 13 例患者收集了 3 个月和 12 个月的随访数据。
结论
PAPPEI 研究旨在扩大我们对 AP 后 PEI 发生率的认识，包括其对营养状况和生活质量的影响。
Zotero 插件