Kelmendi Fatos M, Morina Arsim A, Mekaj Agon Y, Dragusha Shefki, Ahmeti Feti, Alimehmeti Ridvan, Morina Qamile, Berisha Murat, Krasniqi Blerim, Kerolli Berat
Clinic of Neurosurgery, University Clinical Center of Kosovo, Prishtina, Kosovo.
Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Br J Neurosurg. 2023 Feb;37(1):53-58. doi: 10.1080/02688697.2021.1878487. Epub 2021 Feb 10.
Among children who sustain mild traumatic brain injury (mTBI), 10-30% develop a cluster of cognitive, physical, and emotional symptoms commonly referred to as post-concussion syndrome (PCS). Symptoms typically resolve within 7-10 days, but a minority of patients report symptoms that persist for months or even years. The aim of our study was to identify a neurobiochemical marker after mTBI that can predict the presence of post-concussion syndrome three months after head injury in paediatric patients.
Children between 7 and 16 years of age who had head trauma and no other complaints were included. Three months after the initial visit, participants or parents/guardians were interviewed in person about the children's PCS symptoms using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ).
The mean value of S100B protein in serum in 38 patients without signs of PCS was 0.266 μg L, with a 95% confidence interval (CI) of 0.221 - 0.310 μg L. Among the 22 patients with signs of PCS, the mean value of S100B protein in serum was 0.845 μg L, with a 95% CI of 0.745-0.945 μg L. Patients with signs of PCS had higher S100B protein levels than those without signs of PCS ( < 0.0001).
Our prospective study showed that S100B protein is a useful neurobiomarker for detecting paediatric patients at risk for post-concussion syndrome. We found that the biomarker S100B correlated with the severity of traumatic brain injury (number of lesions on CT) and the presence of post-concussion syndrome.
在遭受轻度创伤性脑损伤（mTBI）的儿童中，10% - 30%会出现一系列认知、身体和情感症状，通常称为脑震荡后综合征（PCS）。症状通常在7 - 10天内缓解，但少数患者报告症状会持续数月甚至数年。我们研究的目的是确定mTBI后一种神经生化标志物，该标志物可预测儿科患者头部受伤三个月后脑震荡后综合征的存在情况。
纳入7至16岁有头部外伤且无其他不适主诉的儿童。初次就诊三个月后，使用Rivermead脑震荡后症状问卷（RPQ）对参与者或其父母/监护人进行面对面访谈，了解儿童的PCS症状。
38例无PCS体征患者血清中S100B蛋白的平均值为0.266μg/L，95%置信区间（CI）为0.221 - 0.310μg/L。22例有PCS体征的患者中，血清S100B蛋白的平均值为0.845μg/L，95%CI为0.745 - 0.945μg/L。有PCS体征的患者S100B蛋白水平高于无PCS体征的患者（P<0.0001）。
我们的前瞻性研究表明，S100B蛋白是检测有脑震荡后综合征风险的儿科患者的一种有用的神经生物标志物。我们发现生物标志物S100B与创伤性脑损伤的严重程度（CT上的病灶数量）和脑震荡后综合征的存在情况相关。
