Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467-8603, Japan.
J Biochem. 2021 Jul 3;169(5):511-516. doi: 10.1093/jb/mvab015.
The secreted glycoprotein Reelin plays important roles in both brain development and function. During development, Reelin regulates neuronal migration and dendrite development. In the mature brain, the glycoprotein is involved in synaptogenesis and synaptic plasticity. It has been suggested that Reelin loss or decreased function contributes to the onset and/or deterioration of neuropsychiatric diseases, including schizophrenia and Alzheimer's disease. While the molecular mechanisms underpinning Reelin function remain unclear, recent studies have suggested that the specific proteolytic cleavage of Reelin may play central roles in the embryonic and postnatal brain. In this review, we focus on Reelin proteolytic processing and review its potential physiological roles.
分泌型糖蛋白 Reelin 在大脑发育和功能中都发挥着重要作用。在发育过程中，Reelin 调节神经元迁移和树突发育。在成熟的大脑中，该糖蛋白参与突触形成和突触可塑性。有研究表明，Reelin 的缺失或功能降低会导致神经精神疾病（包括精神分裂症和阿尔茨海默病）的发生和/或恶化。虽然 Reelin 功能的潜在分子机制尚不清楚，但最近的研究表明，Reelin 的特定蛋白水解切割可能在胚胎期和出生后的大脑中发挥核心作用。在这篇综述中，我们重点介绍了 Reelin 的蛋白水解加工，并回顾了其潜在的生理作用。
