Arieli R, Kerem D, Melamed Y
Israel Naval Hyperbaric Institute, Tel-Shikmona, Haifa, Israel.
J Appl Physiol (1985). 1988 Jan;64(1):181-6. doi: 10.1152/jappl.1988.64.1.181.
We tested whether hyperbaric O2 (HBO) has an adverse effect on the hypoxic ventilatory drive. Four groups of rats were exposed for 550 min to O2 at 1.67, 1.90, and 2.15 ATA and to air at 1.90 ATA, respectively. Ventilatory parameters (frequency, tidal volume, and minute ventilation) were measured using whole-body plethysmography, before the hyperbaric exposure, immediately after the exposure, and up to 20 days after the exposure. Resting ventilation was not affected after exposure at 1.90 ATA to air or at 1.67 ATA to O2. HBO at 1.90 and 2.15 ATA caused a reduction of frequency and an elevation of tidal volume at different inspired gases: air, 5% CO2 balance O2, 80% O2, and 4.5% O2. However, minute ventilation on the day after the hyperoxic exposure was not different from the control at either air, 5% CO2, or 80% O2 but was markedly attenuated on the first three breaths at 4.5% O2. The hypoxic ventilation decreased to 48 +/- 13 (SD) and 32 + 11% after 1.90 and 2.15 ATA, respectively. The ventilatory parameters recovered in the days after HBO. We conclude that HBO reversibly depresses the hypoxic ventilatory drive, most probably by a direct effect on the carotid O2 chemoreceptors.
我们测试了高压氧（HBO）是否对低氧通气驱动有不良影响。将四组大鼠分别暴露于1.67、1.90和2.15ATA的氧气以及1.90ATA的空气中550分钟。在高压暴露前、暴露后立即以及暴露后长达20天，使用全身体积描记法测量通气参数（频率、潮气量和分钟通气量）。暴露于1.90ATA的空气或1.67ATA的氧气后，静息通气未受影响。1.90和2.15ATA的HBO在不同的吸入气体（空气、5%二氧化碳平衡氧气、80%氧气和4.5%氧气）下导致频率降低和潮气量升高。然而，高氧暴露后第二天，在空气、5%二氧化碳或80%氧气条件下的分钟通气量与对照组无差异，但在4.5%氧气条件下的前三呼吸时显著减弱。1.90和2.15ATA后，低氧通气分别降至48±13（标准差）和32 + 11%。HBO后数天通气参数恢复。我们得出结论，HBO可逆地抑制低氧通气驱动，很可能是通过对颈动脉氧化学感受器的直接作用。
