Lingam V R, Lazarus L W, Groves L, Oh S H
Walter P. Reuther Psychiatric Hospital, Westland, Mich. 48185.
J Clin Psychiatry. 1988 Apr;49(4):151-3.
The authors retrospectively studied the charts of 25 patients with poststroke depression who were treated with methylphenidate. The 13 patients (52%) who recovered completely from their depression did not differ significantly from the 12 nonresponders on demographic characteristics, location of cerebrovascular accident, and other variables. Mood usually improved within 48 hours; only 3 (12%) patients had side effects. Rapid response to treatment and lack of significant side effects indicate that methylphenidate may be a valuable treatment for poststroke depression.
作者回顾性研究了25例接受哌醋甲酯治疗的中风后抑郁症患者的病历。13例（52%）抑郁症完全康复的患者在人口统计学特征、脑血管意外发生部位及其他变量方面与12例无反应者相比无显著差异。情绪通常在48小时内改善；只有3例（12%）患者有副作用。对治疗的快速反应和无明显副作用表明哌醋甲酯可能是治疗中风后抑郁症的一种有价值的药物。
