Division of Orthodontics, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Division of Orthodontics, Department of Dentistry, Jordanian Royal Medical Services, Amman, Jordan.
Orthod Craniofac Res. 2021 Nov;24(4):459-479. doi: 10.1111/ocr.12476. Epub 2021 Feb 18.
The current systematic review aimed to assess the impact of intraoral non-surgical non-pharmacological adjunctive interventions on orthodontically induced inflammatory root resorption (OIIRR).
Search without restrictions was performed up to November 2020 in three electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE) for randomized controlled trials (RCTs), prospective and retrospective non-randomized studies. The ROB 2.0 tool was used to assess the quality of the included RCTs, and the ROBINS-I tool was applied to non-randomized clinical studies. The strength of evidence was ranked using GRADE.
Three hundred and sixteen records were initially retrieved. A total of 10 studies, with 236 patients, were finally considered. These studies assessed the effects of mechanical vibration (low-frequency and high-frequency), low-intensity pulsed ultrasound (LIPUS), low-level laser therapy (LLLT) and photobiomodulation (light-emitting devices (LED). While the low-frequency vibration and LED do not seem to affect OIIRR, OIIRR has been reported to be reduced in high-frequency vibration, and LIPUS-treated teeth (differences may not likely be considered clinically relevant). The potential positive effect of LLLT on OIIRR is still debatable. Overall, the existing evidence suggests that the amount of OIIRR observed while using these interventions with traditional orthodontic treatment was not more than that was observed without it.
Based on a very low level of confidence, it seems that intraoral non-pharmacological non-surgical adjunctive interventions do not affect the amount of OIIRR either positively or negatively to a clinically relevant degree when compared to what is seen with conventional orthodontic treatment alone.
本系统评价旨在评估口腔内非手术非药物辅助干预措施对正畸诱导的炎症性牙根吸收（OIIRR）的影响。
截至 2020 年 11 月，在三个电子数据库（Cochrane 对照试验中心注册库、MEDLINE 和 EMBASE）中无限制地进行了检索，以纳入随机对照试验（RCT）、前瞻性和回顾性非随机研究。使用 ROB 2.0 工具评估纳入 RCT 的质量，使用 ROBINS-I 工具评估非随机临床研究。使用 GRADE 对证据强度进行分级。
最初检索到 316 条记录。最终共纳入 10 项研究，共 236 例患者。这些研究评估了机械振动（低频和高频）、低强度脉冲超声（LIPUS）、低水平激光治疗（LLLT）和光生物调节（发光二极管）的效果。虽然低频振动和 LED 似乎不会影响 OIIRR，但高频振动和 LIPUS 治疗的牙齿（差异可能不被认为具有临床相关性）报告 OIIRR 减少。LLLT 对 OIIRR 的潜在积极影响仍存在争议。总体而言，现有证据表明，与单独传统正畸治疗相比，使用这些干预措施治疗时观察到的 OIIRR 量并没有增加到具有临床相关性的程度。
基于非常低的置信水平，似乎口腔内非药物非手术辅助干预措施对 OIIRR 的影响在正向或负向上均不具有临床相关性，与单独传统正畸治疗相比，其影响程度没有增加。
