Department of Medical Oncology, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Asia Pac J Clin Oncol. 2021 Aug;17(4):350-358. doi: 10.1111/ajco.13503. Epub 2021 Feb 10.
Multiple studies have observed increasing incidence of small intestinal (SI) neuroendocrine tumours (NETs). The aim of this study was to describe incidence, mortality and survival of SI NETs by sub-site and stage at diagnosis.
Data on patients diagnosed with SI NETs between 2001 and 2015 were sourced from the Queensland Oncology Repository. Staging algorithms utilising several data sources were used to calculate stage at diagnosis (localised, regional or metastatic disease).
We identified 778 SI NETs and of those 716 (92%) had either a documented or derived stage. Incidence doubled from 0.68 per 100 000 to 1.42 per 100 000 over the 15-year period. Most common site was ileum (49.1%) and 84.2% were of carcinoid morphology type. Stage at diagnosis was calculated for 91.7% of patients with 28.3% presenting with regional involvement and 23.9% with distant metastasis. Risk factors associated with metastatic disease were jejunal and SI site not otherwise specified, neuroendocrine carcinoma histology and residing in a rural area. Increasing incidence of localised disease and a corresponding reduction in metastatic disease was observed over time. Five-year cause-specific survival for patients diagnosed between 2001 and 2005 was 82.5%, increasing to 93.8% from 2011 to 2015. Survival was lowest for those with metastatic disease (74.2%). Survival increased between 2001 to 2005 and 2011 to 2015 for each disease stage.
SI NET incidence in Queensland doubled between 2001 and 2015. Survival was high and improved over time.
多项研究观察到小肠（SI）神经内分泌肿瘤（NETs）的发病率不断增加。本研究旨在通过亚部位和诊断时的分期描述 SI NETs 的发病率、死亡率和生存率。
本研究的数据来源于 2001 年至 2015 年间在昆士兰州肿瘤库诊断为 SI NETs 的患者。利用多个数据源的分期算法来计算诊断时的分期（局限性、区域性或转移性疾病）。
我们共确定了 778 例 SI NETs，其中 716 例（92%）有明确或推断的分期。在 15 年期间，发病率从 0.68/100000 增加到 1.42/100000。最常见的部位是回肠（49.1%），84.2%为类癌形态类型。91.7%的患者计算了分期，其中 28.3%为局部区域受累，23.9%为远处转移。与转移性疾病相关的危险因素包括空肠和 SI 部位未特指、神经内分泌癌组织学和居住在农村地区。随着时间的推移，局部疾病的发病率不断增加，而转移性疾病的发病率相应减少。2001 年至 2005 年期间诊断的患者 5 年特异性生存率为 82.5%，而 2011 年至 2015 年期间为 93.8%。转移性疾病患者的生存率最低（74.2%）。每个疾病阶段的生存率在 2001 年至 2005 年和 2011 年至 2015 年之间均有所提高。
2001 年至 2015 年期间，昆士兰州的 SI NETs 发病率增加了一倍。生存率高且随着时间的推移而提高。
