Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
World Neurosurg. 2021 May;149:e455-e459. doi: 10.1016/j.wneu.2021.02.004. Epub 2021 Feb 7.
Rathke cleft cysts (RCCs) are benign sellar lesions originating from remnants of primitive ectoderm. They have not been previously linked to other cystic lesions, such as pineal cysts (PCs). Our objective was to perform a multicenter cross-sectional neuroimaging study to examine prevalence rates of coexisting RCC and PC.
We retrospectively queried prospectively maintained, institutional review board-approved, databases from the authors' centers. All patients undergoing transsphenoidal surgery for RCC between the years of 2011 and 2020 were included for analysis. Preoperative magnetic resonance imaging was reviewed to identify the coexistence of a PC. Patient demographics and neuroimaging characteristics were recorded. A control cohort comprised of 100 age- and sex-matched patients with nonfunctional pituitary adenoma (NFPA) who also underwent surgical intervention was utilized.
Eighty-four patients with RCC were identified for analysis. A coexistent PC was identified in 40.5% (n = 34) of patients with RCC compared with 14.3% (n = 12) in the NFPA cohort (P < 0.001). There was no significant difference in PC size between patients with RCC and PA (8 vs. 8.8 mm, respectively; P = 0.77). Although the majority (85.7%; n = 72) of the RCC cohort were female patients, there was no sex predominance with respect to coexisting PC in either the RCC or PA cohort.
This is the first study to report an increased prevalence of coexisting PC and RCC, possibly because of an embryologic link or other propensity for intracranial cyst formation. Additional studies in more generalizable populations can further explore the relation between RCC and PC, or other cyst formation.
Rathke 裂隙囊肿（RCC）是起源于原始外胚层残余物的良性鞍内病变。它们以前与其他囊性病变（如松果体囊肿（PC））无关。我们的目的是进行一项多中心横断面神经影像学研究，以检查共存的 RCC 和 PC 的患病率。
我们回顾性地查询了作者所在中心前瞻性维护的、机构审查委员会批准的数据库。所有在 2011 年至 2020 年间因 RCC 接受经蝶窦手术的患者均被纳入分析。对术前磁共振成像进行了回顾，以确定是否存在 PC 的共存。记录了患者的人口统计学和神经影像学特征。使用了一个包含 100 名年龄和性别匹配的无功能性垂体腺瘤（NFPA）患者的对照组，这些患者也接受了手术干预。
确定了 84 例 RCC 患者进行分析。在 RCC 患者中，有 40.5%（n=34）存在共存的 PC，而 NFPA 患者中为 14.3%（n=12）（P<0.001）。RCC 和 PA 患者的 PC 大小无显著差异（分别为 8 毫米和 8.8 毫米；P=0.77）。尽管大多数（85.7%；n=72）RCC 患者为女性，但在 RCC 或 PA 患者中，共存的 PC 均无性别优势。
这是第一项报道 RCC 与 PC 共存率增加的研究，这可能是因为胚胎学上的联系或其他颅内囊肿形成的倾向。在更具普遍性的人群中进行更多的研究可以进一步探讨 RCC 与 PC 之间的关系，或与其他囊肿形成的关系。
