Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, Italy.
Museo di Anatomia Umana "Filippo Civinini", Università di Pisa, Italy.
Neuroscientist. 2022 Oct;28(5):411-419. doi: 10.1177/1073858421992316. Epub 2021 Feb 10.
This review addresses, in a critical historical perspective, the link between seizures and endocranic neoplasms. Folkloric descriptions of epilepsy can be found in writings from ancient cultures. Hippocrates first provided a medical interpretation. In 1770, Tissot published , a milestone in epileptology, whereas the 19th century is considered the golden era of epileptic studies. In 1882, the father of modern epileptology, Jackson, in his article , reported a case of a patient affected by typical Jacksonian seizures in the presence of a brain tumor. However, he did not establish a direct correlation between brain tumors and epilepsy, and an explanation for his clinical case was lacking. Before Jackson's article, other authors reported similar cases, but only Gairdner in 1834 published a report suggesting the concept of a direct relationship between epilepsy and a brain tumor. From the beginning until the mid of the 20th century several authors reported seizures attributed to intracranial tumors, and in recent years studies have focused on the pathogenesis of tumor-related seizures. Biochemical and molecular changes in brain tumors and their environment opened unprecedented working hypotheses on epileptogenesis and on treatment of epilepsy associated with brain tumors.
这篇综述从批判的历史角度探讨了癫痫发作与颅内肿瘤之间的联系。在古代文化的著作中可以找到关于癫痫的民间描述。希波克拉底首先提供了医学解释。1770 年，蒂索特（Tissot）发表了，这是癫痫学的一个里程碑，而 19 世纪被认为是癫痫研究的黄金时代。1882 年，现代癫痫学之父杰克逊（Jackson）在他的文章中，报道了一例患有典型杰克逊癫痫的患者存在脑肿瘤的病例。然而，他并没有在脑肿瘤和癫痫之间建立直接的联系，也缺乏对他的临床病例的解释。在杰克逊的文章发表之前，其他作者也报道了类似的病例，但只有盖尔德纳（Gairdner）在 1834 年发表的一份报告提出了癫痫与脑肿瘤之间存在直接关系的概念。从一开始到 20 世纪中叶，有几位作者报道了归因于颅内肿瘤的癫痫发作，近年来，研究的重点集中在肿瘤相关癫痫发作的发病机制上。脑肿瘤及其环境中的生化和分子变化为癫痫发生和治疗与脑肿瘤相关的癫痫开辟了前所未有的工作假说。
