Department of Vascular and Endovascular Surgery and the University Wound Center, Hospital of the Goethe University, Frankfurt/Main, Germany; Department of Vascular Surgery and Endovascular Surgery, Heidelberg University Hospital, Heidelberg, Germany; Institute of Diagnostic and Interventional Radiology, Hospital of the Goethe University, Frankfurt/Main, Germany; German Institute for Vascular Health Research (DIGG) of the German Society for Vascular Surgery and Vascular Medicine (DGG), Berlin, Germany.
Dtsch Arztebl Int. 2020 Oct 20;117(48):813-819. doi: 10.3238/arztebl.2020.0813.
This review presents the surgical indications, surgical procedures, and results in the treatment of asymptomatic and ruptured abdominal aortic aneurysms (AAA).
An updated search of the literature on screening, diagnosis, treatment, and follow-up of AAA, based on the German clinical practice guideline published in 2018.
Surgery is indicated in men with an asymptomatic AAA ≥ 5.5 cm and in women, ≥ 5.0 cm. The indication in men is based on four randomized trials, while in women the data are not conclusive. The majority of patients with AAA (around 80%) meanwhile receive endovascular treatment (endovascular aortic repair, EVAR). Open surgery (open aneurysm repair, OAR) is reserved for patients with longer life expectancy and lower morbidity. The pooled 30-day mortality is 1.16% (95% confidence interval [0.92; 1.39]) following EVAR, 3.27% [2.7; 3.83] after OAR. Women have higher operative/interventional mortality than men (odds ratio 1.67%). The mortality for ruptured AAA is extremely high: around 80% of women and 70% of men die after AAA rupture. Ruptured AAA should, if possible, be treated via the endovascular approach, ideally with the patient under local anesthesia. Treatment at specialized centers guarantees the required expertise and infrastructure. Long-term periodic monitoring by mean of imaging (duplex sonography, plus computed tomography if needed) is essential, particularly following EVAR, to detect and (if appropriate) treat endoleaks, to document stable diameter of the eliminated aneurysmal sac, and to determine whether reintervention is necessary (long-term reintervention rate circa 18%).
Vascular surgery now offers a high degree of safety in the treatment of patients with asymptomatic AAA. Endovascular intervention is preferred.
本文综述了无症状和破裂的腹主动脉瘤(AAA)的手术适应证、手术方法和治疗结果。
根据 2018 年德国临床实践指南,对 AAA 的筛查、诊断、治疗和随访的文献进行了更新检索。
对于无症状 AAA 男性≥5.5cm、女性≥5.0cm,建议进行手术。男性的适应证基于四项随机试验,而女性的数据尚无定论。同时,约 80%的 AAA 患者接受了腔内治疗(血管内修复术,EVAR)。开放手术(开放动脉瘤修复术,OAR)则保留给预期寿命较长和并发症发生率较低的患者。EVAR 后 30 天死亡率为 1.16%(95%置信区间[0.92; 1.39]),OAR 后为 3.27%[2.7; 3.83]。女性的手术/介入死亡率高于男性(比值比 1.67%)。AAA 破裂的死亡率极高:女性约 80%、男性约 70%在 AAA 破裂后死亡。如果可能的话,应通过血管内方法治疗破裂的 AAA,理想情况下在局部麻醉下进行。在专门的中心进行治疗可保证所需的专业知识和基础设施。通过影像学(双功能超声,如有必要加用计算机断层扫描)进行长期定期监测至关重要,尤其是在 EVAR 后,以检测和(如有必要)治疗内漏,记录消除的动脉瘤囊的稳定直径,并确定是否需要再次干预(长期再次干预率约为 18%)。
血管外科现在为治疗无症状 AAA 患者提供了高度的安全性。腔内介入治疗是首选。