Montes Jose M, Montes Paloma, Hernández-Huerta Daniel
Psychiatry Service, CIBERSAM, IRYCIS, Hospital Universitario Ramóny Cajal, Madrid, Spain.
Psychiatry Service, Hospital Universitario de Móstoles Madrid, Spain.
Neuropsychiatr Dis Treat. 2021 Feb 3;17:291-296. doi: 10.2147/NDT.S298005. eCollection 2021.
There are still some unmet needs in the treatment of schizophrenia like the persistence of negative symptoms. Cariprazine is a new-generation antipsychotic with partial agonism of the dopamine receptors, distinct from other antipsychotics by its 10 times greater affinity for D3 receptors. This mechanism of action could be especially favorable on patients with predominant negative symptoms. This report is showing three clinical cases of acute schizophrenia exacerbation that required hospitalization and were successfully treated with cariprazine. All of them had predominant positive symptoms and two of them had substance use. Efficacy of cariprazine was also crucial on negative and cognitive symptoms with excellent tolerability.
精神分裂症的治疗仍存在一些未满足的需求，如阴性症状的持续存在。卡立普嗪是一种新一代抗精神病药物，对多巴胺受体具有部分激动作用，与其他抗精神病药物不同的是，它对D3受体的亲和力高10倍。这种作用机制可能对以阴性症状为主的患者特别有利。本报告展示了3例急性精神分裂症加重的临床病例，这些患者需要住院治疗，并使用卡立普嗪成功治愈。他们均以阳性症状为主，其中2例有物质使用问题。卡立普嗪对阴性和认知症状也有显著疗效，耐受性良好。
