家族性多发性硬化症。

Familial multiple sclerosis.

作者信息

Hartung H P, Will R G, Francis D, Grosse-Wilde H, Rudge P, Scaravilli F, Hennerici M, McDonald W I

机构信息

Department of Neurology, University of Düsseldorf, F.R.G.

出版信息

J Neurol Sci. 1988 Feb;83(2-3):259-68. doi: 10.1016/0022-510x(88)90073-1.

DOI:10.1016/0022-510x(88)90073-1

PMID:3356992

Abstract

Siblings of patients with multiple sclerosis have an increased risk of developing the disease. In this report we describe 3 families with multiple affected members, representing the largest published aggregation of cases in first degree relatives. In the 2 families in which HLA tissue-typing was performed the affected individuals shared part of the haplotype HLA-DR2 (+ HLA-DQW1), BfS (+ C2C), C4A3, C4B1. The implications of these findings for the aetiology of multiple sclerosis are discussed.

摘要

多发性硬化症患者的兄弟姐妹患该病的风险增加。在本报告中，我们描述了3个有多名患病成员的家庭，这是已发表的一级亲属中病例聚集数量最多的情况。在进行了HLA组织分型的2个家庭中，患病个体共享部分单倍型HLA - DR2（+ HLA - DQW1）、BfS（+ C2C）、C4A3、C4B1。讨论了这些发现对多发性硬化症病因学的意义。