有机光氧化还原催化的杂原子亲核试剂、烯烃和脂肪族氧化还原活性酯的三组分偶联反应。
Organophotoredox-Catalyzed Three-Component Coupling of Heteroatom Nucleophiles, Alkenes, and Aliphatic Redox Active Esters.
机构信息
Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
出版信息
Org Lett. 2021 Mar 5;23(5):1798-1803. doi: 10.1021/acs.orglett.1c00211. Epub 2021 Feb 11.
This manuscript describes a visible-light-mediated organophotoredox catalytic process for vicinal difunctionalization of alkenes using heteroatom nucleophiles and aliphatic redox active esters. A wide range of heteroatom nucleophiles including alcohols, water, carboxylic acids, amides, and halogens can be used for this reaction. This radical relay type reaction allows forging of C(sp)-C(sp) with a carbon-centered radical and C(sp)-heteroatom bonds with a benzyl cation on the vinylarenes with complete regioselectivity in a single step.
这篇手稿描述了一种可见光介导的有机光氧化还原催化过程，用于使用杂原子亲核试剂和脂肪族氧化还原活性酯对烯烃进行邻位双官能化。该反应可以使用多种杂原子亲核试剂，包括醇、水、羧酸、酰胺和卤素。这种自由基接力反应允许通过碳中心自由基形成 C(sp)-C(sp)键，并通过苄基阳离子形成 C(sp)-杂原子键，在单个步骤中具有完全的区域选择性。
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