Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan R.O.C.
Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan R.O.C.
Org Lett. 2021 Mar 5;23(5):1904-1909. doi: 10.1021/acs.orglett.1c00330. Epub 2021 Feb 11.
Meleagrin B is a terpene-alkaloid hybrid natural product that contains both the conidiogenone and meleagrin scaffold. Their derivatives show diverse biological activities. We characterized the biosynthesis of (-)-conidiogenone B (), which involves a diterpene synthase and a P450 monooxygenase. In addition, an α,β-hydrolase (Con-ABH) was shown to catalyze an aza-Michael addition between and imidazole to give -imidazolyl conidiogenone B (). Compound was more potent than against strains.
美拉红碱 B 是一种萜类生物碱杂合天然产物，同时含有康皮定酮和美拉红碱骨架。它们的衍生物表现出多种生物活性。我们对 (-)-康皮定酮 B () 的生物合成进行了表征，其中涉及二萜合酶和 P450 单加氧酶。此外，还表明 α,β-水解酶 (Con-ABH) 可以催化 和咪唑之间的aza-Michael 加成反应，生成 -咪唑基康皮定酮 B ()。化合物 对 株的活性强于 。
