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Drug-induced sarcoidosis-like reaction in adjuvant immunotherapy: Increased rate and mimicker of metastasis.佐剂免疫治疗中的药物诱导的类肉瘤样反应：转移的发生率增加和类似物。
Eur J Cancer. 2020 May;131:18-26. doi: 10.1016/j.ejca.2020.02.024. Epub 2020 Apr 2.
2
PD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8 T cell Induced Death.PD-1/PD-L1 通路调节巨噬细胞对结核分枝杆菌特异性 CD8 T 细胞诱导的死亡的敏感性。
Sci Rep. 2019 Jan 17;9(1):187. doi: 10.1038/s41598-018-36403-2.
3
Tuberculosis following PD-1 blockade for cancer immunotherapy.癌症免疫治疗后发生 PD-1 阻断相关的结核。
Sci Transl Med. 2019 Jan 16;11(475). doi: 10.1126/scitranslmed.aat2702.
4
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.程序性死亡受体-1（PD-1）缺陷型小鼠对结核分枝杆菌感染极为敏感。
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13402-7. doi: 10.1073/pnas.1007394107. Epub 2010 Jul 12.
5
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.被感染单核细胞的凋亡而非坏死，与细胞内卡介苗的杀灭相关。
J Exp Med. 1994 Oct 1;180(4):1499-509. doi: 10.1084/jem.180.4.1499.

上皮样肉芽肿性病变表达丰富的程序性死亡配体-1（PD-L1）：抗 PD-1 抗体为基础的癌症免疫治疗的不良反应讨论。

Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy.

机构信息

Department of Pathology, Sapporo Medical University, School of Medicine, Sapporo, Japan.

Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, Japan.

出版信息

Hum Vaccin Immunother. 2021 Jul 3;17(7):1940-1942. doi: 10.1080/21645515.2020.1870364. Epub 2021 Feb 11.

DOI:10.1080/21645515.2020.1870364
PMID:33570446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8189068/
Abstract

The immune system is often called a double-edged sword, due to the inextricable link between cancer immunity and allergy/autoimmunity. Intriguingly, a growing number of cases have been reported in which PD-1 blockade triggers the exacerbation of tuberculosis (TB), an organ-invasive granulomatous disease caused by bacterial infection. As a result, the exacerbation of TB is now considered a severe adverse effect of nivolumab and pembrolizumab. In this letter, we report the strong expression of PD-L1 in epithelioid granulomatous lesions in tuberculosis, sarcoidosis, Crohn's disease, and foreign body granuloma. In addition, we discussed the exacerbation of tuberculosis after anti-PD-1 antibody-based cancer immunotherapy.

摘要

免疫系统常被称为双刃剑，这是由于癌症免疫与过敏/自身免疫之间存在着千丝万缕的联系。有趣的是，越来越多的病例报告称，PD-1 阻断会引发结核（TB）恶化，TB 是一种由细菌感染引起的器官侵袭性肉芽肿性疾病。因此，TB 恶化现在被认为是 nivolumab 和 pembrolizumab 的严重不良反应。在这封信中，我们报告了 PD-L1 在结核、结节病、克罗恩病和异物肉芽肿中的上皮样肉芽肿病变中的强表达。此外，我们还讨论了抗 PD-1 抗体癌症免疫疗法后结核恶化的问题。