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预处理 HCT 嵌合体增加了异基因 HCT 后急性淋巴细胞白血病患者的复发风险并降低了生存率。

Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post-unrelated HCT.

机构信息

College of Pharmacy, The Ohio State University, Columbus, OH.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

出版信息

Blood Adv. 2021 Jan 12;5(1):66-70. doi: 10.1182/bloodadvances.2020003366.

DOI:10.1182/bloodadvances.2020003366
PMID:33570634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7805319/
Abstract

Pre-HCT mosaicism is related to increased relapse risk and lower survival after unrelated HCT, independent of cytogenetics at diagnosis. Pre-HCT mosaicism could be a useful clinical tool to guide risk stratification in acute lymphoblastic leukemia patients.

摘要

预处理 HCT 嵌合体与无关 HCT 后复发风险增加和生存率降低有关，与诊断时的细胞遗传学无关。预处理 HCT 嵌合体可能是指导急性淋巴细胞白血病患者风险分层的有用临床工具。

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本文引用的文献

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Monogenic and polygenic inheritance become instruments for clonal selection.单基因遗传和多基因遗传成为克隆选择的工具。
Nature. 2020 Aug;584(7819):136-141. doi: 10.1038/s41586-020-2430-6. Epub 2020 Jun 24.
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无关供者造血干细胞移植治疗急性髓系白血病患者移植前外周血染色体异常对预后的影响。
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Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex.在异基因移植患者中，与B细胞急性淋巴细胞白血病的基因关联因年龄和性别而异。
Blood Adv. 2017 Sep 8;1(20):1717-1728. doi: 10.1182/bloodadvances.2017006023. eCollection 2017 Sep 12.
6
Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant.异基因血液或骨髓移植后与生存相关的基因多态性的复制与验证。
Blood. 2017 Sep 28;130(13):1585-1596. doi: 10.1182/blood-2017-05-784637. Epub 2017 Aug 15.
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The ageing genome, clonal mosaicism and chronic disease.衰老的基因组、克隆镶嵌现象与慢性疾病。
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