地屈孕酮影响斑马鱼胚胎固有免疫和凝血级联反应相关基因的转录。
Dydrogesterone Affects the Transcription of Genes in Innate Immune and Coagulation Cascade in Zebrafish Embryos.
机构信息
Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, SCNU Environmental Research Institute, South China Normal University, Guangzhou, 510006, China.
School of Environment, South China Normal University, University Town, Guangzhou, 510006, China.
出版信息
Bull Environ Contam Toxicol. 2021 Apr;106(4):594-599. doi: 10.1007/s00128-021-03127-5. Epub 2021 Feb 11.
Dydrogesterone (DDG) acts on the reproduction but also affects the functioning of non-reproductive system. So far, the knowledge about other effects of DDG remains limited. Here we investigated the effects of DDG on the transcription of genes in innate immune and coagulation cascade in zebrafish embryos. The zebrafish embryos were exposed to DDG at 49.0, 527 and 5890 ng L for 144 hour post fertilization (hpf). The results showed that DDG significantly decreased the transcription of marker genes (e.g. tnfa, il8 and cc-chem) involved in the innate immune response at environmental concentrations. Moreover, DDG also down-regulated the transcription of genes in coagulation cascade (e.g. fga, fgb, fgg and f2). These results indicated that DDG had potential effects on the innate immune and coagulation cascade functions in the early life zebrafish, thus further affecting fish growth and health.
地屈孕酮（DDG）不仅作用于生殖系统，还影响非生殖系统的功能。到目前为止，关于 DDG 的其他作用的知识仍然有限。在这里，我们研究了 DDG 对斑马鱼胚胎固有免疫和凝血级联中基因转录的影响。斑马鱼胚胎在受精后 144 小时（hpf）暴露于 49.0、527 和 5890 ng/L 的 DDG 下。结果表明，DDG 在环境浓度下显著降低了参与固有免疫反应的标记基因（如 tnfa、il8 和 cc-chem）的转录。此外，DDG 还下调了凝血级联中基因的转录（如 fga、fgb、fgg 和 f2）。这些结果表明，DDG 对早期生活斑马鱼的固有免疫和凝血级联功能具有潜在影响，从而进一步影响鱼类的生长和健康。
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