Max Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, 1030 Vienna, Austria.
Int J Mol Sci. 2021 Feb 9;22(4):1745. doi: 10.3390/ijms22041745.
Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reelin to ApoER2 and VLDLR and phosphorylation of Dab1 mediated by Src family kinases. Here we show that Dab1 also acts as an adaptor for epidermal growth factor receptor (EGFR) and can be phosphorylated by epidermal growth factor (EGF) binding to EGFR. Phosphorylation of Dab1 depends on the kinase activity of EGFR constituting a signal pathway independent of Reelin and its receptors.
失活 1 (Dab1) 是极低密度脂蛋白受体 (VLDLR) 和载脂蛋白 E 受体 2 (ApoER2) 的衔接蛋白，也是 Reelin 途径的一个组成部分，该途径在胚胎大脑发育过程中协调神经元分层。Dab1 的激活是由 Reelin 与 ApoER2 和 VLDLR 的结合以及Src 家族激酶介导的 Dab1 的磷酸化诱导的。在这里，我们表明 Dab1 也作为表皮生长因子受体 (EGFR) 的衔接蛋白起作用，并且可以通过表皮生长因子 (EGF) 与 EGFR 的结合而被磷酸化。Dab1 的磷酸化取决于 EGFR 的激酶活性，构成了一条独立于 Reelin 及其受体的信号通路。
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