Tsuchiya M, Yanagisawa A, Kitagawa T, Ogawa M, Hashida I, Kaneta K
Gan No Rinsho. 1988 Mar;34(3):251-7.
This is the histopathological analysis of 18 post-irradiated brains with metastases of breast cancers. There was no evidence of radiation necrosis, except for one with demyelinization and one with degeneration of nerve cells. There was no radiation damage in re-irradiated group. Whole brain irradiation of about 40 Gy may be safe, but that of 60 Gy or more may be not so safe. It may be more useful for preventing of radiation damage to take split-course-method or shrinking-technique at doses of 40 Gy or more. The combination of chemotherapy and radiation therapy seems to aggravate the course of radiation damage.
这是对18例患有乳腺癌转移的放疗后脑组织进行的组织病理学分析。除1例有脱髓鞘改变和1例有神经细胞变性外，未发现放射性坏死的证据。再照射组未出现放射损伤。全脑照射约40 Gy可能是安全的，但60 Gy或更高剂量可能就不那么安全了。在40 Gy或更高剂量时采用分割疗程法或缩野技术可能对预防放射损伤更有用。化疗与放疗联合似乎会加重放射损伤的病程。
