Hoshino K, Mizushima Y, Yano S, Kitagawa M
1st Dept. of Internal Med., Toyama Medical & Pharmaceutical Univ.
Gan No Rinsho. 1988 Apr;34(4):491-6.
A 76-year-old man with lung carcinoma, who was undergoing both radiotherapy and chemotherapy (CDDP + ADR) suddenly died with the onset of abdominal symptoms. Autopsy disclosed that the main cause of death was suppurative panperitonitis, caused by a perforation of a metastatic lesion at the jejunum. A histological examination revealed extensive tumor necrosis in the metastatic liver lesions as well as in the jejunal lesions. Neither inflammatory nor circulatory damage was observed in the perforated lesion. Therefore, the cause of this perforation was considered to be chemotherapy that had brought on tumor necrosis. No similar reports of lung cancer deaths have been found in the literature in which the microscopic details were described. Accordingly, this case is reported for future reference with regard to cancer chemotherapy.
一名76岁的肺癌男性患者，正在接受放疗和化疗（顺铂+阿霉素），突然出现腹部症状并死亡。尸检显示，主要死因是化脓性全腹膜炎，由空肠转移性病变穿孔所致。组织学检查发现，转移性肝病变和空肠病变均有广泛的肿瘤坏死。穿孔病变处未观察到炎症或循环损伤。因此，认为这种穿孔的原因是化疗导致的肿瘤坏死。文献中未发现有类似描述微观细节的肺癌死亡报告。因此，报告此病例以供未来癌症化疗参考。
