1-(乙基)-1-(2-羟乙基)氯化氮丙啶在水介质中的形成与降解——一项比较核磁共振研究

Formation and degradation of 1-(ethyl)-1-(2-hydroxyethyl) aziridinium chloride in aqueous media--a comparative NMR study.

作者信息

Goldstein S, Grimee R, Hanin I, Wulfert E

机构信息

UCB S.A., Pharmaceutical Sector, Braine-l'Alleud, Belgium.

出版信息

J Neurosci Methods. 1988 Mar;23(2):101-5. doi: 10.1016/0165-0270(88)90181-1.

DOI:10.1016/0165-0270(88)90181-1

PMID:3357352

Abstract

The formation and decomposition of 1-(ethyl)-1-(2-hydroxyethyl) aziridinium chloride in aqueous media (10 mM solutions) was studied by NMR spectroscopy. Compared to 1-diethyl aziridinium chloride which lacks the hydroxyl group, the degradation of the title compound at 37 degrees C and pH = 7.4 is about 10 times faster. However, liquid nitrogen frozen solutions of both aziridinium salts are stable for long periods of time (1-6 months).

摘要

通过核磁共振光谱法研究了1-(乙基)-1-(2-羟乙基)氯化氮丙啶在水介质（10 mM溶液）中的形成与分解。与不含羟基的1-二乙基氯化氮丙啶相比，标题化合物在37℃和pH = 7.4时的降解速度快约10倍。然而，两种氮丙啶盐的液氮冷冻溶液在很长一段时间（1 - 6个月）内都是稳定的。