[Effect of lactic bacteria metabolic products on the transmission of R-plasmids in enterobacteria in vitro].

The authors present data on the study of lactobacteria used in the production of dry lactobacterin (lactobacterinum siccum). Metabolic products (lactocidin) were extracted with lactic and acetic acid after Vincent et al. Two donor strains (E. coli K12 J5-3 R1-19 and E. coli K12 W1845 R26) were crossed in the conjugation process in various conbinations with six recipient strains (E. coli K12S, E. coli Su 3912/41, Sh. sonnei 263B, Sh. sonnel 3470, S. heidelberg, A161, and S. typhimurium SH3 his-). The frequency of R-plasmide transmission in enterobacteria was decreased in vitro under the effect of L. plantarum 8R-A3 and L. fermentum 90T-S4 metabolites.