Yuan Chunjue, Li Ruoyun, Liu Guohong, Pan Yunbao
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Front Pharmacol. 2021 Jan 26;11:609212. doi: 10.3389/fphar.2020.609212. eCollection 2020.
At the beginning of 2020, a sudden outbreak of new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infections led to anxiety, panic, and crisis among people worldwide. The outbreak first occurred in Wuhan, China, in late December 2019 and then spread rapidly across the globe, thus becoming a major public health emergency. Although the current epidemic situation in China tends to be stable, coronavirus disease 2019 (COVID-19) continues to spread globally. At present, no specific therapeutic drugs and vaccines are available against COVID-19. Also, the pathogenesis of the SARS-CoV-2 is not fully clear. Human immunity is important in SARS-CoV-2 infection. Studies have shown that excessive inflammation caused by SARS-CoV-2 infection and subsequent induced uncontrolled cytokine storm are the main causes of disease deterioration and death of severe patients. Therefore, immune-related research is of great significance for the prevention, control, and prognosis of COVID-19. This study aimed to review the latest research on immune-related treatment of COVID-19.
2020年初，新型冠状病毒即严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的突然爆发，在全球范围内引发了人们的焦虑、恐慌和危机。此次疫情于2019年12月底在中国武汉首次出现，随后迅速蔓延至全球，进而成为一场重大的突发公共卫生事件。尽管目前中国的疫情趋于稳定，但2019冠状病毒病（COVID-19）仍在全球持续传播。目前，尚无针对COVID-19的特效治疗药物和疫苗。此外，SARS-CoV-2的发病机制也尚未完全明确。人体免疫在SARS-CoV-2感染中起着重要作用。研究表明，SARS-CoV-2感染引起的过度炎症以及随后诱发的不受控制的细胞因子风暴是重症患者病情恶化和死亡的主要原因。因此，免疫相关研究对于COVID-19的预防、控制和预后具有重要意义。本研究旨在综述COVID-19免疫相关治疗的最新研究情况。
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