• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

没食子儿茶素-间苯三酚-6,6-二苯甲酰基倍他环糊精通过调节小鼠主动脉内皮间质转化减轻高脂饮食诱导的高血压。

Pyrogallol-Phloroglucinol-6 6-Bieckol on Attenuates High-Fat Diet-Induced Hypertension by Modulating Endothelial-to-Mesenchymal Transition in the Aorta of Mice.

机构信息

Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, Republic of Korea.

Functional Cellular Networks Laboratory, College of Medicine, Department of Medicine, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.

出版信息

Oxid Med Cell Longev. 2021 Jan 26;2021:8869085. doi: 10.1155/2021/8869085. eCollection 2021.

DOI:10.1155/2021/8869085
PMID:33574986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7857897/
Abstract

Endothelial-to-mesenchymal transition (EndMT), which is involved in the development of various cardiovascular diseases, is induced by dyslipidemia or obesity. In dyslipidemia, the increased levels of oxidized low-density lipoproteins (oxLDL) upregulated the lectin-type oxidized LDL receptor 1 (Lox-1), which then upregulated the down signaling pathways of PKC-/MMPs/TGF-/SMAD2 or 3 and increased the EndMT. In this study, we investigated the effect of pyrogallol-phloroglucinol-6,6-bieckol (PPB), which is a compound of (), on decreased blood pressure (BP) by attenuating the EndMT in a high-fat diet- (HFD-) fed animal model. We also investigated PPB's attenuation effect on EndMT in oxLDL-treated mouse endothelial cells as an model. The results indicated that, in the aorta or endothelial cells of mice, the HFD or oxLDL treatment significantly increased the expression of Lox-1/PKC-/MMP9/TGF-/SMAD2/SMAD3. The PPB treatment significantly decreased its expression. In contrast, the HFD or oxLDL treatment significantly decreased the expression of the EC markers (PECAM-1 and vWF) while the PPB treatment significantly increased them. Moreover, the HFD or oxLDL treatment significantly increased the expression of the mesenchymal cell markers (-SMA and vimentin) while PPB treatment significantly decreased them. PPB decreased the intima-media thickness and extracellular matrix amount of the aorta and attenuated the BP, which was increased by the HFD. In conclusion, PPB attenuated the upregulation of Lox-1/PKC-/MMP9/TGF-/SMAD2 and 3 and restored the EndMT in HFD-fed animals. Moreover, PPB showed a restoring effect on HFD-induced hypertension.

摘要

内皮细胞向间充质细胞转化（EndMT）参与多种心血管疾病的发生，由血脂异常或肥胖引起。在血脂异常中，氧化型低密度脂蛋白（oxLDL）水平升高会上调凝集素型氧化型 LDL 受体 1（Lox-1），从而上调 PKC-/MMPs/TGF-/SMAD2 或 3 的下游信号通路，并增加 EndMT。在这项研究中，我们研究了焦棓酚-棓酚-6,6-二酮（PPB）对高脂饮食喂养动物模型中 EndMT 的抑制作用，以降低血压（BP）的效果。我们还研究了 PPB 在 oxLDL 处理的小鼠内皮细胞中的抑制 EndMT 的作用，作为氧化应激模型。结果表明，在小鼠的主动脉或内皮细胞中，HFD 或 oxLDL 处理显著增加了 Lox-1/PKC-/MMP9/TGF-/SMAD2/SMAD3 的表达。PPB 处理显著降低了其表达。相反，HFD 或 oxLDL 处理显著降低了 EC 标志物（PECAM-1 和 vWF）的表达，而 PPB 处理显著增加了它们的表达。此外，HFD 或 oxLDL 处理显著增加了间充质细胞标志物（-SMA 和波形蛋白）的表达，而 PPB 处理显著降低了它们的表达。PPB 降低了主动脉的内中膜厚度和细胞外基质量，并减轻了 HFD 引起的 BP 升高。总之，PPB 抑制了 HFD 喂养动物中 Lox-1/PKC-/MMP9/TGF-/SMAD2 和 3 的上调，并恢复了 EndMT。此外，PPB 对 HFD 诱导的高血压显示出恢复作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/269aa00b1cfa/OMCL2021-8869085.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/9985bc1e672d/OMCL2021-8869085.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/3ee294db5144/OMCL2021-8869085.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/4f46e1b79582/OMCL2021-8869085.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/eb327446174c/OMCL2021-8869085.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/30dfa5c366a1/OMCL2021-8869085.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/269aa00b1cfa/OMCL2021-8869085.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/9985bc1e672d/OMCL2021-8869085.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/3ee294db5144/OMCL2021-8869085.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/4f46e1b79582/OMCL2021-8869085.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/eb327446174c/OMCL2021-8869085.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/30dfa5c366a1/OMCL2021-8869085.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd7f/7857897/269aa00b1cfa/OMCL2021-8869085.006.jpg

相似文献

1
Pyrogallol-Phloroglucinol-6 6-Bieckol on Attenuates High-Fat Diet-Induced Hypertension by Modulating Endothelial-to-Mesenchymal Transition in the Aorta of Mice.没食子儿茶素-间苯三酚-6,6-二苯甲酰基倍他环糊精通过调节小鼠主动脉内皮间质转化减轻高脂饮食诱导的高血压。
Oxid Med Cell Longev. 2021 Jan 26;2021:8869085. doi: 10.1155/2021/8869085. eCollection 2021.
2
The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas.没食子酸-间苯三酚-6,6-贝壳杉烯醇对高脂饮食诱导的小鼠主动脉内皮和血管平滑肌细胞细胞焦亡的抑制作用。
Mar Drugs. 2020 Dec 16;18(12):648. doi: 10.3390/md18120648.
3
Attenuating Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on Vascular Smooth Muscle Cell Phenotype Changes to Osteoblastic Cells and Vascular Calcification Induced by High Fat Diet.没食子酸-间苯三酚-6,6-贝壳杉烯醇对高脂饮食诱导的血管平滑肌细胞向成骨细胞表型转化及血管钙化的抑制作用。
Nutrients. 2020 Sep 11;12(9):2777. doi: 10.3390/nu12092777.
4
Pyrogallol-Phloroglucinol-6,6-Bieckolon Attenuates Vascular Smooth Muscle Cell Proliferation and Phenotype Switching in Hyperlipidemia through Modulation of Chemokine Receptor 5.没食子儿茶素-间苯三酚-6,6-双醚抑制趋化因子受体 5 下调高脂血症血管平滑肌细胞增殖及表型转化
Mar Drugs. 2020 Jul 27;18(8):393. doi: 10.3390/md18080393.
5
Pyrogallol-Phloroglucinol-6,6'-Bieckol from Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models.没食子儿茶素-间苯三酚-6,6'-双咖啡酰基奎宁酸改善饮食诱导肥胖和高血压模型小鼠的血液循环。
Mar Drugs. 2019 May 8;17(5):272. doi: 10.3390/md17050272.
6
SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition.SIRT1 激活通过内皮细胞向间充质转化减轻心脏纤维化。
Biomed Pharmacother. 2019 Oct;118:109227. doi: 10.1016/j.biopha.2019.109227. Epub 2019 Jul 24.
7
Ginkgo biloba extract inhibits oxidized low-density lipoprotein (oxLDL)-induced matrix metalloproteinase activation by the modulation of the lectin-like oxLDL receptor 1-regulated signaling pathway in human umbilical vein endothelial cells.银杏叶提取物通过调节人脐静脉内皮细胞中凝集素样氧化低密度脂蛋白受体1调控的信号通路，抑制氧化低密度脂蛋白（oxLDL）诱导的基质金属蛋白酶激活。
J Vasc Surg. 2016 Jan;63(1):204-15.e1. doi: 10.1016/j.jvs.2014.05.098. Epub 2014 Jul 28.
8
Extract Attenuates Endothelial Cell Dysfunction by Modulation of Inflammation and Brown Adipocyte Function in Perivascular Fat Tissue.提取物通过调节血管周围脂肪组织中的炎症和棕色脂肪细胞功能来减轻内皮细胞功能障碍。
Nutrients. 2019 Nov 15;11(11):2795. doi: 10.3390/nu11112795.
9
High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.孕期高胆固醇饮食可诱导小鼠母体血管功能障碍：氧化 LDL 诱导的 LOX-1 和 AT1 受体激活的潜在作用。
Clin Sci (Lond). 2020 Sep 18;134(17):2295-2313. doi: 10.1042/CS20200764.
10
Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling.氯沙坦通过抑制TGF-β/Smad信号通路减轻自发性高血压大鼠心肌内皮-间充质转化
PLoS One. 2016 May 13;11(5):e0155730. doi: 10.1371/journal.pone.0155730. eCollection 2016.

引用本文的文献

1
siLOXL2 Inhibits Endothelial Inflammatory Response and EndMT Induced by ox-LDL.siLOXL2 抑制 ox-LDL 诱导的内皮炎症反应和 EndMT。
Cerebrovasc Dis Extra. 2024;14(1):165-176. doi: 10.1159/000541906. Epub 2024 Oct 17.
2
Marine Pharmacology in 2019-2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.2019-2021 年海洋药理学：具有抗菌、抗糖尿病、抗真菌、抗炎、抗原生动物、抗结核和抗病毒活性的海洋化合物；影响免疫系统和神经系统以及其他各种作用机制。
Mar Drugs. 2024 Jun 30;22(7):309. doi: 10.3390/md22070309.
3

本文引用的文献

1
Attenuating Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on Vascular Smooth Muscle Cell Phenotype Changes to Osteoblastic Cells and Vascular Calcification Induced by High Fat Diet.没食子酸-间苯三酚-6,6-贝壳杉烯醇对高脂饮食诱导的血管平滑肌细胞向成骨细胞表型转化及血管钙化的抑制作用。
Nutrients. 2020 Sep 11;12(9):2777. doi: 10.3390/nu12092777.
2
Pyrogallol-Phloroglucinol-6,6'-Bieckol from Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models.没食子儿茶素-间苯三酚-6,6'-双咖啡酰基奎宁酸改善饮食诱导肥胖和高血压模型小鼠的血液循环。
Mar Drugs. 2019 May 8;17(5):272. doi: 10.3390/md17050272.
3
Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction.
糖尿病血管并发症的共同发病机制：聚焦于代谢紊乱、免疫炎症和内皮功能障碍的相互作用。
Cell Commun Signal. 2023 Oct 30;21(1):298. doi: 10.1186/s12964-022-01016-w.
4
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions.血管功能和高血压中的信号通路：分子机制和治疗干预。
Signal Transduct Target Ther. 2023 Apr 20;8(1):168. doi: 10.1038/s41392-023-01430-7.
5
Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression.血管紧张素 II 型受体通过抑制 LOX-1 改善脂质紊乱来防止人腹膜间皮细胞细胞外基质积聚。
Ren Fail. 2022 Dec;44(1):1687-1697. doi: 10.1080/0886022X.2022.2133729.
6
Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis.氧化型低密度脂蛋白介导的内皮功能障碍机制及其对动脉粥样硬化发展的影响
Front Cardiovasc Med. 2022 Jun 1;9:925923. doi: 10.3389/fcvm.2022.925923. eCollection 2022.
7
Pyrogallol-Phloroglucinol-6, 6-Bieckol Restored Primary Cilia Length, Which Was Decreased by High-Fat Diet in Visceral Adipose Tissue, and Decreased Adipogenesis.连苯三酚-间苯三酚-6,6-二聚间苯三酚恢复了原发性纤毛长度，该长度因高脂饮食在内脏脂肪组织中缩短，并且减少了脂肪生成。
Int J Endocrinol. 2022 Apr 16;2022:8486965. doi: 10.1155/2022/8486965. eCollection 2022.
8
Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective.蛋白激酶C-δ在心血管疾病中的作用及机制：现状与展望
Front Cardiovasc Med. 2022 Feb 15;9:816369. doi: 10.3389/fcvm.2022.816369. eCollection 2022.
9
Generation and identification of endothelial-specific Hrh2 knockout mice.内皮细胞特异性 Hrh2 敲除小鼠的建立与鉴定。
Transgenic Res. 2021 Jun;30(3):251-261. doi: 10.1007/s11248-021-00244-z. Epub 2021 Mar 30.
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.
心血管疾病中的内皮细胞向间充质细胞转化：JACC 前沿综述。
J Am Coll Cardiol. 2019 Jan 22;73(2):190-209. doi: 10.1016/j.jacc.2018.09.089.
4
Endothelial to mesenchymal transition in atherosclerotic vascular remodeling.动脉粥样硬化血管重构中的内皮间质转化。
Clin Chim Acta. 2019 Mar;490:34-38. doi: 10.1016/j.cca.2018.12.018. Epub 2018 Dec 17.
5
Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from on Monocyte-Associated Vascular Dysfunction.没食子酸-间苯三酚-6,6-贝壳杉烯醇对单核细胞相关血管功能障碍的保护作用。
Mar Drugs. 2018 Nov 9;16(11):441. doi: 10.3390/md16110441.
6
Oxidized low density lipoprotein induces endothelial-to-mesenchymal transition by stabilizing Snail in human aortic endothelial cells.氧化型低密度脂蛋白通过稳定人主动脉内皮细胞中的 Snail 诱导内皮细胞向间充质细胞转化。
Biomed Pharmacother. 2018 Oct;106:1720-1726. doi: 10.1016/j.biopha.2018.07.122. Epub 2018 Jul 30.
7
Fluid shear stress regulates the expression of Lectin-like oxidized low density lipoprotein receptor-1 via KLF2-AP-1 pathway depending on its intensity and pattern in endothelial cells.流体切应力通过 KLF2-AP-1 通路调节内皮细胞中 Lectin-like 氧化型低密度脂蛋白受体-1 的表达，其表达强度和模式取决于流体切应力。
Atherosclerosis. 2018 Mar;270:76-88. doi: 10.1016/j.atherosclerosis.2018.01.038. Epub 2018 Jan 31.
8
Endothelial-mesenchymal transition in atherosclerosis.动脉粥样硬化中的血管内皮-间充质转化。
Cardiovasc Res. 2018 Mar 15;114(4):565-577. doi: 10.1093/cvr/cvx253.
9
Notch Signaling in Endothelial Cells: Is It the Therapeutic Target for Vascular Neointimal Hyperplasia?内皮细胞中的Notch信号通路：它是血管内膜增生的治疗靶点吗？
Int J Mol Sci. 2017 Jul 25;18(8):1615. doi: 10.3390/ijms18081615.
10
Carotid artery intima-media thickness and hypertensive heart disease: a short review.颈动脉内膜中层厚度与高血压性心脏病：简要综述
Clin Hypertens. 2017 Apr 2;23:7. doi: 10.1186/s40885-017-0063-3. eCollection 2017.