Department of Orthopedic Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
Osteoporos Int. 2021 Jun;32(6):1233-1237. doi: 10.1007/s00198-021-05880-z. Epub 2021 Feb 11.
The authors present a rare case of multiple vertebral compression fractures in a young female with iatrogenic glucocorticoid-induced Cushing syndrome and concomitant human immunodeficiency virus (HIV) infection. Both long-term steroid use and HIV infection may lead to osteopenia or even osteoporosis. Multiple vertebral fractures in young patients are very uncommon and should alert the examiner to investigate any underlying cause. Treatment choices include pharmacological agents such as bisphosphonates or parathyroid hormone and even surgical interventions such as percutaneous vertebroplasty.
作者报告了一例罕见的年轻女性病例,该患者因医源性糖皮质激素诱导的库欣综合征和同时感染人类免疫缺陷病毒(HIV)而发生多处椎体压缩性骨折。长期使用类固醇和 HIV 感染都可能导致骨质减少,甚至骨质疏松。年轻患者的多处椎体骨折非常罕见,应引起检查者警惕,以调查任何潜在病因。治疗选择包括双膦酸盐或甲状旁腺激素等药物治疗,甚至包括经皮椎体成形术等手术干预。