Fletcher David F, Chaugule Vishal, Gomes Dos Reis Larissa, Young Paul M, Traini Daniela, Soria Julio
School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, Australia.
Laboratory for Turbulence Research in Aerospace and Combustion (LTRAC), Department of Mechanical and Aerospace Engineering, Monash University, Clayton Campus, Melbourne, Australia.
Pharm Res. 2021 Feb;38(2):277-288. doi: 10.1007/s11095-020-02981-y. Epub 2021 Feb 11.
Computational Fluid Dynamics (CFD) simulations are performed to investigate the impact of adding a grid to a two-inlet dry powder inhaler (DPI). The purpose of the paper is to show the importance of the correct choice of closure model and modeling approach, as well as to perform validation against particle dispersion data obtained from in-vitro studies and flow velocity data obtained from particle image velocimetry (PIV) experiments.
CFD simulations are performed using the Ansys Fluent 2020R1 software package. Two RANS turbulence models (realisable k - ε and k - ω SST) and the Stress Blended Eddy Simulation (SBES) models are considered. Lagrangian particle tracking for both carrier and fine particles is also performed.
Excellent comparison with the PIV data is found for the SBES approach and the particle tracking data are consistent with the dispersion results, given the simplicity of the assumptions made.
This work shows the importance of selecting the correct turbulence modelling approach and boundary conditions to obtain good agreement with PIV data for the flow-field exiting the device. With this validated, the model can be used with much higher confidence to explore the fluid and particle dynamics within the device.
进行计算流体动力学（CFD）模拟，以研究在双入口干粉吸入器（DPI）中添加格栅的影响。本文的目的是展示正确选择封闭模型和建模方法的重要性，并针对从体外研究获得的颗粒分散数据以及从粒子图像测速（PIV）实验获得的流速数据进行验证。
使用Ansys Fluent 2020R1软件包进行CFD模拟。考虑了两种雷诺平均纳维-斯托克斯（RANS）湍流模型（可实现k-ε和k-ω SST）以及应力混合涡模拟（SBES）模型。还对载体颗粒和细颗粒进行了拉格朗日粒子跟踪。
对于SBES方法，发现与PIV数据具有出色的对比，并且鉴于所作假设的简单性，粒子跟踪数据与分散结果一致。
这项工作表明选择正确的湍流建模方法和边界条件对于使流出设备的流场与PIV数据取得良好一致性的重要性。经过验证后，该模型可以更有信心地用于探索设备内的流体和颗粒动力学。
