Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Mol Divers. 2022 Feb;26(1):589-628. doi: 10.1007/s11030-021-10194-7. Epub 2021 Feb 11.
Fukuyama reaction for the synthesis of multifunctional aldehydes, secondary amines and ketones has gained considerable importance in synthetic organic chemistry because of mild reaction conditions. The use of thioesters in both Fukuyama aldehydes and ketones synthesis is highly attractive for organic chemists as they are easily accessible from corresponding carboxylic acids. Fukuyama-Mitsunobu reaction utilizes 2-nitrobenzenesulfonyl (Ns) for the protection/activation/deprotection of primary amines to afford secondary amines in good yields and high enantioselectivities. This review presents recent synthetic developments and applications of Fukuyama reaction for the synthesis of aldehydes, secondary amines and ketones.
福山反应在合成多功能醛、仲胺和酮方面具有重要意义，因为其反应条件温和。硫酯在福山醛和酮合成中的应用对有机化学家具有很大的吸引力，因为它们可以很容易地从相应的羧酸中获得。福山-米斯纳布反应利用 2-硝基苯磺酰基（Ns）来保护/活化/脱保护伯胺，以高产率和高对映选择性得到仲胺。本文综述了福山反应在合成醛、仲胺和酮方面的最新合成进展和应用。
