Department of Chemistry, Institute for Coatings and Surface Chemistry, Niederrhein University of Applied Sciences, Adlerstr. 1, 47798, Krefeld, Germany.
Northeast Forestry University, Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Hexing Road 26, 150040, Harbin, China.
Angew Chem Int Ed Engl. 2021 May 3;60(19):10983-10991. doi: 10.1002/anie.202015677. Epub 2021 Mar 17.
Carbon nanodots (CDs) originating from different biomass result in different activities to sensitize photo-ATRP and photo-CuAAC reaction protocols with visible light. Free radical polymerization of tri(propylene glycol)diacrylate also exhibited a good efficiency using CDs in combination with an iodonium salt employing LEDs emitting either at 405 nm, 525 nm or 660 nm. Photo-ATRP experiments confirmed controlled polymerization conditions using Cu at the ppm scale resulting in dispersities between 1.06 to 1.10. Chain end fidelity was successfully provided by chain extension and block copolymerization additionally approving the living feature of polymerization using a CD synthesized from lac dye comprising olefinic moieties in the originating biomass. By global analysis, time resolved fluorescence measurements indicated the appearance of several emitting species contributing to the reactivity of the excited states. Different cytotoxic response appeared following the answer of MCF-10A cells in a flow cytometry assay; that is 400 μg mL . Thus, cell viability was greater 80 % in the case of CD-2-CD-5 while that of CD-1 was close to 70 %.
碳纳米点（CDs）源自不同的生物质，导致在使用可见光敏化光引发原子转移自由基聚合（photo-ATRP）和铜催化的叠氮-炔环加成反应（photo-CuAAC）反应时表现出不同的活性。使用 CDs 与碘鎓盐结合，在发射波长为 405nm、525nm 或 660nm 的 LED 照射下，三（丙二醇）二丙烯酸酯的自由基聚合也表现出了很好的效率。photo-ATRP 实验证实，使用 ppm 级别的 Cu 可以实现控制聚合条件，得到的分散度在 1.06 到 1.10 之间。通过链延伸和嵌段共聚反应，提供了链端保真度，进一步证明了使用源自含有双键的生物质的漆染料合成的 CD 进行聚合的活性。通过全局分析，时间分辨荧光测量表明，几种发光物质的出现有助于激发态的反应性。在流式细胞术测定中， MCF-10A 细胞的反应显示出不同的细胞毒性响应；即 400μg/mL 时，CD-2-CD-5 的细胞活力大于 80%，而 CD-1 则接近 70%。
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