College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China.
Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, China.
J Magn Reson Imaging. 2021 Aug;54(2):586-595. doi: 10.1002/jmri.27541. Epub 2021 Feb 11.
Schizophrenia (SC) and bipolar disorder (BP) share elements of symptoms and the underlying neural mechanisms for both remain unclear. Recently, the complexity of spontaneous functional MRI (fMRI) signals in brain activity has been investigated in SC and BP using multiscale sample entropy (MSE) with inconsistent results.
To perform MSE analysis across five time scales to assess differences in resting-state fMRI signal complexity in SC, BP, and normal controls (NC).
Retrospective.
Fifty SC, 49 BP, and 49 NC.
FIELD STRENGTH/SEQUENCE: A 3 T, T2* weighted echo planar imaging (EPI) sequence.
The mean MSEs of all gray matter (GM) and of 12 regions of interest (ROIs) were extracted using masks across the five scales. The regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in these ROIs were also determined and the relationship between the three measures was investigated. The correlations between cognitive assessment scores and MSE values were also explored.
Bonferroni correction, One-way ANOVA, Spearman rank correlation coefficient (r), Gaussian random field (GRF) correction.
There were decreased GM MSE values in the patient groups (F = 9.629, P < 0.05). SC and BP patients demonstrated lower complexity than NCs in the calcarine fissure, precuneus, inferior occipital gyrus, lingual gyrus and cerebellum, and higher complexity in the median cingulate, thalamus, hippocampus, middle temporal gyrus and middle frontal gyrus. There were significant differences between SC and BP patients in the precuneus (F = 4.890, P < 0.05) and inferior occipital gyrus (F = 5.820, P < 0.05). Calcarine fissure, cingulate, temporal gyrus, occipital gyrus, hippocampus, precuneus, frontal gyrus, and lingual gyrus MSE values were significantly correlated with both ReHo (r > 0.282, P < 0.05) and ALFF (r > 0.278, P < 0.05). Furthermore, median temporal MSE (r = -0.321, P < 0.05) on scale 3 and (r = -0.307, P < 0.05) on scale 4 and median cingulate MSE (r = -0.337, P < 0.05) on scale 5 was significantly negatively correlated with cognitive assessment scores.
These data highlight different patterns of brain signal intensity complexity in SC and BP.
1 TECHNICAL EFFICACY: Stage 1.
精神分裂症（SC）和双相情感障碍（BP）在症状上存在相似之处，其潜在的神经机制仍不清楚。最近，使用多尺度样本熵（MSE）对 SC 和 BP 中的自发功能磁共振成像（fMRI）信号的复杂性进行了研究，但结果不一致。
通过 MSE 分析五个时间尺度，评估 SC、BP 和正常对照组（NC）静息状态 fMRI 信号复杂性的差异。
回顾性研究。
50 例 SC、49 例 BP 和 49 例 NC。
场强/序列：3T，T2*加权回波平面成像（EPI）序列。
使用跨五个尺度的掩模提取所有灰质（GM）和 12 个感兴趣区域（ROI）的平均 MSE。还确定了这些 ROI 中的局部一致性（ReHo）和低频波动幅度（ALFF），并研究了这三个测量值之间的关系。还探讨了认知评估评分与 MSE 值之间的相关性。
Bonferroni 校正，单因素方差分析，Spearman 秩相关系数（r），高斯随机场（GRF）校正。
患者组的 GM MSE 值降低（F=9.629，P<0.05）。与 NC 相比，SC 和 BP 患者在距状裂、楔前叶、枕下回、舌回和小脑的脑区表现出较低的复杂性，而在扣带回中部、丘脑、海马、颞中回和额中回的脑区表现出较高的复杂性。在楔前叶（F=4.890，P<0.05）和枕下回（F=5.820，P<0.05），SC 和 BP 患者之间存在显著差异。距状裂、扣带回、颞叶、枕叶、海马、楔前叶、额中回和舌回的 MSE 值与 ReHo（r>0.282，P<0.05）和 ALFF（r>0.278，P<0.05）均呈显著正相关。此外，第三尺度上的中颞叶 MSE（r=-0.321，P<0.05）和第四尺度上的中颞叶 MSE（r=-0.307，P<0.05）以及第五尺度上的扣带回中部 MSE（r=-0.337，P<0.05）与认知评估评分呈显著负相关。
这些数据突出了 SC 和 BP 中不同的脑信号强度复杂性模式。
1 技术功效：第 1 阶段。
