Nikolajuk-Stasiuk Julita, Lapinski Tadeusz W
Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Poland, Poland.
Ginekol Pol. 2021;92(1):30-34. doi: 10.5603/GP.a2020.0139.
The incidence of HBV infections among the pregnant in Europe falls within the range of 1-7%, whereas it is 1.7-4.3% for HCV. The aim was to assess the course of pregnancy among women infected with HBV or HCV, and the condition of neonates in the fifth minute after the birth.
The study included 157 pregnant individuals infected with HBV, 53 infected with HCV, and 330 healthy pregnant women. None of the women infected with HBV and HCV as well as from the control group were infected with HIV, and none of them took intoxicants.
Weight of neonates delivered by healthy women was higher as compared with children born by women infected with HBV or HCV (3.517 vs 3.347 and 3.366). The Apgar score of neonates delivered by women with HBV and HCV infections was lower as compared with the children born by healthy women (9.4 vs 9.3 vs 9.7; p < 0.05). Premature births occurred more often in HBV and HCV-infected women than in the control group (14.6% and 24.5% vs 6.96%; p < 0.05). Miscarriages were significantly more common among the patients with HCV infections as compared with the patients who were healthy (9.4% vs 1.8%; p < 0.05). In comparison with the healthy individuals, this group of patients experienced pruritus (10.5% vs 4.2%; p < 0.05), oedemas (9.4% vs 2.4%; p < 0.05), and hypertension (9.4% vs 1.5%; p < 0.05) more often. An increase in HBV loads was observed between the 6th and 28th-32nd week of pregnancy among the infected with HBV, and then, a decrease was observed in the 6th months after the delivery.
The women infected with HBV without HBsAg (-) and the infected with HCV are subject to common incidence of premature births. Women infected with HCV often experience oedemas, hypertension, and pruritus.
欧洲孕妇中乙肝病毒（HBV）感染率在1% - 7%之间，丙型肝炎病毒（HCV）感染率为1.7% - 4.3%。本研究旨在评估HBV或HCV感染孕妇的妊娠过程以及新生儿出生后五分钟的状况。
本研究纳入了157例HBV感染孕妇、53例HCV感染孕妇以及330例健康孕妇。HBV和HCV感染的女性以及对照组女性均未感染HIV，且均未使用过毒品。
健康女性所分娩新生儿的体重高于HBV或HCV感染女性所分娩的新生儿（3.517 vs 3.347和3.366）。HBV和HCV感染女性所分娩新生儿的阿氏评分低于健康女性所分娩的新生儿（9.4 vs 9.3 vs 9.7；p < 0.05）。HBV和HCV感染女性的早产发生率高于对照组（14.6%和24.5% vs 6.96%；p < 0.05）。与健康患者相比，HCV感染患者的流产明显更为常见（9.4% vs 1.8%；p < 0.05）。与健康个体相比，该组患者更常出现瘙痒（10.5% vs 4.2%；p < 0.05）、水肿（9.4% vs 2.4%；p < 0.05）和高血压（9.4% vs 1.5%；p < 0.05）。在妊娠第6周至第28 - 32周期间，观察到HBV感染孕妇的HBV载量增加，然后在分娩后6个月观察到载量下降。
未出现乙肝表面抗原（HBsAg）阴性的HBV感染女性和HCV感染女性早产发生率较高。HCV感染女性常出现水肿、高血压和瘙痒。
