Department of Pediatrics, Okmeydanı Training and Medical Research Hospital, University of Health Science, İstanbul, Turkey
Department of Pediatric Endocrinology, Okmeydanı Training and Medical Research Hospital, University of Health Science, İstanbul, Turkey
Turk J Med Sci. 2021 Jun 28;51(3):1396-1405. doi: 10.3906/sag-2009-187.
BACKGROUND/AIM: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients.
The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in the control group. In addition, serum amyloid A (SAA), and fibrinogen levels were measured, and a mutation analysis was performed in the patient group. The results were compared among the attack-free period, acute attack FMF and control groups.
The mean age of patients and control group was 10 (2.5–18) and 9.5 (2.5–16) years, respectively. The CRP (p = 0.001), S100A12 (p = 0.003) and ESR (p= 0.001) values differed significantly between the FMF and control groups. S100A12 level (p = 0.027), WBC count (p = 0.003), CRP level (p = 0.0001), ESR (p = 0.004), and fibrinogen level (p = 0.001) differed significantly between the acute attack and attack-free period groups. SAA level (p = 0.05), ESR (p = 0.001), fibrinogen level (p = 0.001), WBC count (p = 0.001), and S100A12 level (p = 0.027) were higher in M694V homozygous FMF patients than in other FMF patients.
Patients with FMF had higher S100A12 levels than the control group, while the mean S100A12 concentration was higher in acute attack period patients than in attack-free period patients. S100A12 level might be an important indicator in the monitoring of chronic inflammation in patients with FMF.
背景/目的：家族性地中海热（FMF）是儿童中最常见的自身炎症性疾病，其特征是反复发作的发热。已知 FMF 会随着慢性炎症而进展，尤其是在发作期间。本研究旨在探讨炎症标志物 S100A12 与 FMF 患者发作和炎症事件的关系。
该研究纳入了 57 名确诊为 FMF 的患者，其中 43 名处于无发作期，14 名处于发作期，31 名健康儿童作为对照组。仅对对照组进行白细胞（WBC）计数、C 反应蛋白（CRP）水平、红细胞沉降率（ESR）和 S100A12 水平分析。此外，还测量了血清淀粉样蛋白 A（SAA）和纤维蛋白原水平，并对患者组进行了突变分析。比较了无发作期、急性发作 FMF 组和对照组之间的结果。
患者和对照组的平均年龄分别为 10（2.5-18）岁和 9.5（2.5-16）岁。CRP（p=0.001）、S100A12（p=0.003）和 ESR（p=0.001）值在 FMF 组和对照组之间有显著差异。S100A12 水平（p=0.027）、WBC 计数（p=0.003）、CRP 水平（p=0.0001）、ESR（p=0.004）和纤维蛋白原水平（p=0.001）在急性发作期和无发作期组之间有显著差异。SAA 水平（p=0.05）、ESR（p=0.001）、纤维蛋白原水平（p=0.001）、WBC 计数（p=0.001）和 S100A12 水平（p=0.027）在 M694V 纯合 FMF 患者中高于其他 FMF 患者。
FMF 患者的 S100A12 水平高于对照组，而急性发作期患者的平均 S100A12 浓度高于无发作期患者。S100A12 水平可能是监测 FMF 患者慢性炎症的重要指标。
