Holzinger Dirk, Foell Dirk, Kessel Christoph
Department of Pediatric Hematology-Oncology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany.
Department of Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, Domagkstr. 3, 48149, Muenster, Germany.
Mol Cell Pediatr. 2018 Sep 25;5(1):7. doi: 10.1186/s40348-018-0085-2.
S100A8/A9 and S100A12 are released from activated monocytes and granulocytes and act as proinflammatory endogenous toll-like receptor (TLR)4-ligands. S100 serum concentrations correlate with disease activity, both during local and systemic inflammatory processes. In some autoinflammatory diseases such as familial Mediterranean fever (FMF) or systemic juvenile idiopathic arthritis (SJIA), dysregulation of S100 release may be involved in the pathogenesis. Moreover, S100 serum levels are a valuable supportive tool in the diagnosis of SJIA in fever of unknown origin. Furthermore, S100 levels can be used to monitor disease activity to subclinical level, as their serum concentrations decrease with successful treatment.
S100A8/A9和S100A12从活化的单核细胞和粒细胞中释放出来，并作为促炎内源性 Toll 样受体 (TLR)4配体发挥作用。在局部和全身炎症过程中，S100血清浓度均与疾病活动相关。在某些自身炎症性疾病中，如家族性地中海热 (FMF) 或系统性幼年特发性关节炎 (SJIA)，S100释放失调可能参与发病机制。此外，S100血清水平在不明原因发热的SJIA诊断中是一种有价值的辅助工具。此外，S100水平可用于将疾病活动监测至亚临床水平，因为随着治疗成功，其血清浓度会降低。
