Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):932-940. doi: 10.26355/eurrev_202101_24662.
Some studies showed specific associations of the Lactase persistence (LP) genotype (CT/TT) with obesity and its related comorbidities. The aim of the present investigation was to describe the association of rs4988235 with metabolic parameters, diabetes mellitus type 2 (DM2), dairy product consumption in menopausal obese females.
The study involved a population of 86 menopausal obese females. Measurements of anthropometric parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, bone metabolism biomarkers, and prevalence of (DM2) were recorded. The genotype of the Lactase gene polymorphism (rs48988235) was evaluated.
The distribution of the rs48988235 polymorphism was 16.3% (n=14) (CC), 38.4% (n=33) (CT) and 45.3% (n=39) (TT). The allele frequency was C (0.35) and T (0.65). In the recessive model, serum 25-OH Vitamin D, fasting glucose levels, insulin levels, and HOMA-IR were better in CC+CT genotype than TT genotype. In a dominant model, 25-OH Vitamin D, fasting glucose levels, insulin levels, and HOMA-IR were better in CC genotype than CT+TT genotype. In both genetic models, calcium, vitamin D, and milk intakes were higher in T allele carriers. In the dominant model (CT+TT genotype), logistic regression analysis showed an increased risk of hyperglycemia (OR=3.63, 95% CI=1.10-13.26, p=0.03) and prevalence of DM2 (OR=3.93, 95% CI=1.07-14.4, p=0.03), after adjusting by milk intake, BMI, and age. This association remained in recessive model (TT genotype); risk of hyperglycemia (OR=4.26, 95% CI=1.12-16.23, p=0.02) and prevalence of DM2 (OR=5.35, 95% CI=1.12-15.8, p=0.02).
T allele of rs48988235 variant in Lactase gene is associated with better glucose metabolism and lower risk of DM2 in menopausal obese females. In addition, dietary intakes of milk, calcium, and 25-OH vitamin D were higher too.
一些研究表明，乳糖酶持续存在（LP）基因型（CT/TT）与肥胖及其相关合并症之间存在特定关联。本研究旨在描述 rs4988235 与代谢参数、2 型糖尿病（DM2）、绝经后肥胖女性乳制品消费的关系。
本研究纳入了 86 名绝经后肥胖女性。记录了人体测量参数、血压、空腹血糖、胰岛素浓度、胰岛素抵抗（HOMA-IR）、血脂谱、骨代谢生物标志物以及（DM2）的患病率。评估了乳糖基因多态性（rs48988235）的基因型。
rs48988235 多态性的分布为 16.3%（n=14）（CC）、38.4%（n=33）（CT）和 45.3%（n=39）（TT）。等位基因频率为 C（0.35）和 T（0.65）。在隐性模型中，CC+CT 基因型的血清 25-羟维生素 D、空腹血糖水平、胰岛素水平和 HOMA-IR 优于 TT 基因型。在显性模型中，CC 基因型的血清 25-羟维生素 D、空腹血糖水平、胰岛素水平和 HOMA-IR 优于 CT+TT 基因型。在两种遗传模型中，T 等位基因携带者的钙、维生素 D 和牛奶摄入量较高。在显性模型（CT+TT 基因型）中，逻辑回归分析显示，在调整了牛奶摄入量、BMI 和年龄后，高血糖的风险增加（OR=3.63，95%CI=1.10-13.26，p=0.03）和 DM2 的患病率（OR=3.93，95%CI=1.07-14.4，p=0.03）。这种关联在隐性模型（TT 基因型）中仍然存在；高血糖的风险（OR=4.26，95%CI=1.12-16.23，p=0.02）和 DM2 的患病率（OR=5.35，95%CI=1.12-15.8，p=0.02）。
乳糖酶基因 rs48988235 变体的 T 等位基因与绝经后肥胖女性的葡萄糖代谢更好和 2 型糖尿病的风险较低有关。此外，牛奶、钙和 25-羟维生素 D 的膳食摄入量也较高。
