INSERM, U695, Genetic Determinants of Type 2 Diabetes and Its Vascular Complications, Paris, France; Univ Paris Diderot, Sorbonne Paris Cité, UMRS 695, UFR de Médecine Site Bichat, Paris, France.
Metabolism. 2013 Sep;62(9):1323-9. doi: 10.1016/j.metabol.2013.04.006. Epub 2013 May 3.
The T allele of a functional polymorphism (rs4988235: LCT-13910 C>T), close to the lactase gene, correlates with lactase persistence (LP) in adults. The LP genotype (TT+TC) has been associated with a higher BMI in European populations in cross-sectional studies. In the French D.E.S.I.R. cohort, a high consumption of dairy products was associated with a lower body weight gain over 9-years, and with a lower incidence of high plasma glucose levels and/or the metabolic syndrome. Our aim was to test in this study, the association of rs4988235 with BMI and related metabolic diseases, in interaction with dairy product consumption.
Among 5212 subjects from D.E.S.I.R., 3575 Caucasians born in mainland France were genotyped and followed over 9years.
Those with the LP genotype (frequency: 78.5%) had a higher dairy product consumption, at inclusion and at year-9 (P<0.001). They also had a higher BMI at both time points (difference=0.3kg/m(2), P=0.05), but this effect was restricted to medium/high dairy product consumers (difference=0.5kg/m(2), P=0.006). This genotype was also associated with the metabolic syndrome (IDF definition), but this association disappeared after adjustment for BMI. In the whole population, the C allele was associated with a higher prevalence of impaired fasting glycemia and/or type 2 diabetes.
The lactase persistence genotype was shown to be associated with a higher BMI in a longitudinal study, mainly in those consuming high amounts of dairy products. The association of the C allele, responsible for lactase non-persistence, with the risk of hyperglycemia needs to be replicated.
乳糖酶基因附近的功能性多态性（rs4988235：LCT-13910 C>T）的 T 等位基因与成人乳糖持续存在（LP）相关。LP 基因型（TT+TC）与欧洲人群的横断面研究中较高的 BMI 相关。在法国 D.E.S.I.R.队列中，高乳制品消费与 9 年内体重增加较低以及高血糖水平和/或代谢综合征的发生率较低相关。我们的目的是在这项研究中，测试 rs4988235 与 BMI 和相关代谢疾病的关联，以及与乳制品消费的相互作用。
在 D.E.S.I.R.中的 5212 名受试者中，3575 名法国大陆出生的白种人进行了基因分型并随访了 9 年。
LP 基因型（频率：78.5%）的乳制品消费较高，在纳入时和 9 年后（P<0.001）。他们在两个时间点的 BMI 也较高（差异=0.3kg/m2，P=0.05），但这种影响仅限于中/高乳制品消费者（差异=0.5kg/m2，P=0.006）。这种基因型也与代谢综合征（IDF 定义）相关，但这种关联在调整 BMI 后消失。在整个人群中，C 等位基因与空腹血糖受损和/或 2 型糖尿病的患病率较高相关。
在一项纵向研究中，乳糖持续存在的基因型与 BMI 较高相关，主要在摄入大量乳制品的人群中。负责乳糖酶非持续存在的 C 等位基因与高血糖风险的关联需要进一步证实。
