欧洲角膜移植的实践模式：欧洲角膜与细胞移植登记处的首次报告
Practice patterns of corneal transplantation in Europe: first report by the European Cornea and Cell Transplantation Registry.
作者信息
Dunker Suryan L, Armitage W John, Armitage Margareta, Brocato Lucia, Figueiredo Francisco C, Heemskerk Martin B A, Hjortdal Jesper, Jones Gary L A, Konijn Cynthia, Nuijts Rudy M M A, Lundström Mats, Dickman Mor M
机构信息
From the University Eye Clinic, Maastricht University Medical Center+, The Netherlands (Dunker, Nuijts, Dickman); Translational Health Sciences, University of Bristol, United Kingdom (Armitage); Tissue and Eye Services, NHS Blood and Transplant, Bristol, United Kingdom (Armitage); European Eye Bank Association, Venice, Italy (Armitage, Jones); Department of Ophthalmology, Sahlgrenska University Hospital, Gothenburg, Sweden (Armitage); European Society of Cataract and Refractive Surgeons, Dublin, Ireland (Brocato, Nuijts, Lundström); Department of Ophthalmology, Royal Victoria Infirmary and Newcastle University, Newcastle upon Tyne, United Kingdom (Figueiredo); Dutch Transplant Foundation, Leiden, The Netherlands (Heemskerk, Konijn); Department of Ophthalmology, Aarhus University Hospital, Denmark (Hjortdal); European Society of Cornea and Ocular Surface Disease Specialists, Dublin, Ireland (Hjortdal); The Veneto Eye Bank Foundation, Venice, Italy (Jones); Department of Clinical Sciences, Ophthalmology, Faculty of Medicine, Lund University, Lund, Sweden (Lundström).
出版信息
J Cataract Refract Surg. 2021 Jul 1;47(7):865-869. doi: 10.1097/j.jcrs.0000000000000574.
PURPOSE
To report practice patterns of corneal transplantation in Europe.
SETTING
Corneal clinics in 10 European member states (MS), the United Kingdom, and Switzerland.
DESIGN
Multinational registry study.
METHODS
Corneal transplant procedures registered in the European Cornea and Cell Transplantation Registry were identified. Preoperative donor and recipient characteristics, indication and reason for transplantation, and surgical techniques were analyzed.
RESULTS
A total of 12 913 corneal transplants were identified from 10 European Union MS, the United Kingdom, and Switzerland. Most countries were self-sufficient with regard to donor tissue. Fuchs endothelial corneal dystrophy was the most common indication (41%, n = 5325), followed by regraft (16%, n = 2108), pseudophakic bullous keratopathy (12%, n = 1594), and keratoconus (12%, n = 1506). Descemet stripping automated endothelial keratoplasty (DSAEK, 46%, n = 5918) was the most commonly performed technique, followed by penetrating keratoplasty (30%, n = 3886) and Descemet membrane endothelial keratoplasty (9%, n = 1838). Vision improvement was the main reason for corneal transplantation (90%, n = 11 591). Surgical technique and reason for transplantation differed between indications.
CONCLUSIONS
This report provides the most comprehensive overview of corneal transplantation practice patterns in Europe to date. Fuchs endothelial dystrophy is the most common indication, vision improvement the leading reason, and DSAEK the predominant technique for corneal transplantation.
目的
报告欧洲角膜移植的实践模式。
背景
欧洲10个成员国、英国和瑞士的角膜诊所。
设计
跨国登记研究。
方法
确定在欧洲角膜和细胞移植登记处登记的角膜移植手术。分析术前供体和受体特征、移植指征和原因以及手术技术。
结果
从欧盟10个成员国、英国和瑞士共确定了12913例角膜移植手术。大多数国家在供体组织方面能够自给自足。富克斯内皮角膜营养不良是最常见的指征（41%，n = 5325），其次是再次移植（16%，n = 2108）、人工晶状体性大泡性角膜病变（12%，n = 1594）和圆锥角膜（12%，n = 1506）。深板层内皮角膜移植术（DSAEK，46%，n = 5918）是最常施行的技术，其次是穿透性角膜移植术（PK，30%，n = 3886）和后弹力层内皮角膜移植术（DMEK，9%，n = 1838）。视力改善是角膜移植的主要原因（90%，n = 11591）。不同指征的手术技术和移植原因有所不同。
结论
本报告提供了迄今为止欧洲角膜移植实践模式最全面的概述。富克斯内皮营养不良是最常见的指征，视力改善是主要原因，DSAEK是角膜移植的主要技术。
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