DEPARTMENT OF INTERVENTIONAL CARDIOLOGY, JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE, INSTITUTE OF CARDIOLOGY, JOHN PAUL II HOSPITAL, CRACOW, POLAND.
DEPARTMENT OF INVASIVE CARDIOLOGY, ELECTROTHERAPY AND ANGIOLOGY, JOHN PAUL II HOSPITAL, KROSNO, POLAND.
Wiad Lek. 2020;73(12 cz 1):2598-2606.
Introduction: Index of microcirculatory resistance assessment is an invasive method of measuring coronary microcirculation function. Association between impaired microcirculatory function and higher rate of cardiovascular events was proven. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio seem to be a promising parameters to predict coronary microcirculatory disease in patients with chronic coronary syndrome. The aim: To determine neutrophil-lymphocyte ratio and platelet-lymphocyte ratio levels in patients with coronary microcirculatory disease and potential association with clinical outcome.
Material and methods: 82 consecutive patients with mean age of 67 years, 67% male, were tested for presence of coronary microcirculatory disease using index of microcirculatory resistance. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were calculated based on admission full blood count. Follow-up with major adverse cardiac and cardiovascular events registration was performed (median 24 months).
Results: The study showed significantly higher neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with coronary microcirculatory disease compared to control group (3.58±2.61 vs 2.54±1.09 and 164±87.9 vs 124±36.6 respectively). Higher level of platelet-lymphocyte ratio in patients with coronary microcirculatory disease results in worse MACCE-free survival. Optimal cut-off values of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio to detect coronary microcirculatory disease were 3.2 and 181.3, respectively.
Conclusions: Higher neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are associated with increased index of microcirculatory resistance value. Platelet-lymphocyte ratio may be used as a predictor of worse outcome in patients with coronary microcirculatory disease.
引言：评估微血管阻力指数是一种评估冠状动脉微循环功能的有创方法。已经证明，微血管功能受损与心血管事件发生率升高有关。中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值似乎是预测慢性冠脉综合征患者冠状动脉微血管疾病的有前途的参数。目的：确定冠状动脉微血管疾病患者的中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值水平及其与临床结果的潜在相关性。
材料和方法：82 例连续患者，平均年龄 67 岁，男性占 67%，使用微血管阻力指数检测是否存在冠状动脉微血管疾病。基于入院全血计数计算中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值。进行主要不良心脏和心血管事件注册的随访（中位数 24 个月）。
结果：研究表明，与对照组相比，冠状动脉微血管疾病患者的中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值显著升高（3.58±2.61 对 2.54±1.09 和 164±87.9 对 124±36.6）。冠状动脉微血管疾病患者血小板/淋巴细胞比值较高，导致 MACCE 无事件生存率较差。中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值检测冠状动脉微血管疾病的最佳截断值分别为 3.2 和 181.3。
结论：较高的中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与较高的微血管阻力指数值相关。血小板/淋巴细胞比值可作为预测冠状动脉微血管疾病患者不良结局的指标。
