Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Medicine (Baltimore). 2021 Feb 12;100(6):e24602. doi: 10.1097/MD.0000000000024602.
The purpose of this study was to identify and compare the diagnostic performance of gadolinium-ethoxybenzyl-diethyltriethylenetriacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) in hepatocellular carcinoma (HCC).Two researchers searched PubMed, EMBASE, and Cochrane Library databases from the inception of each database to 10 February 2020, to find comparative studies of Gd-EOB-DTPA-MRI and CEUS in detection of HCC.The study included eight studies (374 patients). MRI is superior to CEUS in diagnostic sensitivity of HCC, P = .03. The diagnostic sensitivity of MRI in lesions with a diameter of less than 30 mm was significantly higher than that of CEUS, P = .04. MRI and CEUS had no significant difference in diagnostic specificity of HCC, P = .95. Summary Receiver Operating Characteristics (SROC) of MRI showed a larger than that of CEUS, but with P > .05.Gd-EOB-DTPA-MRI showed higher sensitivity than CEUS for hepatocellular carcinoma lesions, especially for lesions of less than 30 mm across.
本研究旨在比较钆塞酸二钠（Gd-EOB-DTPA）增强磁共振成像（MRI）与对比增强超声（CEUS）在肝细胞癌（HCC）诊断中的性能。两位研究人员检索了从各数据库建立到 2020 年 2 月 10 日的 PubMed、EMBASE 和 Cochrane Library 数据库，以寻找 Gd-EOB-DTPA-MRI 和 CEUS 检测 HCC 的比较研究。该研究共纳入 8 项研究（374 例患者）。MRI 在 HCC 的诊断灵敏度方面优于 CEUS，P = 0.03。MRI 对直径小于 30mm 的病灶的诊断灵敏度明显高于 CEUS，P = 0.04。MRI 和 CEUS 在 HCC 的诊断特异性方面无显著差异，P = 0.95。MRI 的 SROC 曲线下面积大于 CEUS，但 P＞0.05。Gd-EOB-DTPA-MRI 对肝细胞癌病灶的敏感性高于 CEUS，特别是对直径小于 30mm 的病灶。
