Division of Gastroenterology.
Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Medicine (Baltimore). 2021 Feb 12;100(6):e24623. doi: 10.1097/MD.0000000000024623.
Acute esophageal necrosis (AEN) is a rare syndrome with characteristic endoscopic and pathologic findings. It usually results from a combination of tissue hypoperfusion, impaired local defense barriers, and massive reflux of gastric contents. We report a case of AEN after a kidney transplant.
A 53-year-old man with hypertension and end-stage renal disease presented with abdominal pain and a single episode of hematemesis 14 days after kidney transplantation.
Upper endoscopy revealed circumferential black coloration in the mid to lower esophageal mucosa. Esophageal biopsy showed ulcer, and immunostains were negative for viral etiology.
Conservative management was done with total parenteral nutrition and proton pump inhibitor.
The patient experienced no further episodes of hematemesis or abdominal pain and follow-up endoscopy showed remarkable changes from the black mucosa to a red friable mucosa with whitish exudates.
In the case, AEN occurred in the setting of normal blood pressure after major surgery despite the absence of preceding factors such as hypotension and infections. The possibility of AEN should be considered in patients with solid organ transplantation who present with abdominal pain, dysphagia, and hematemesis.
急性食管坏死(AEN)是一种罕见的综合征,具有特征性的内镜和病理表现。它通常是由于组织低灌注、局部防御屏障受损以及胃内容物大量反流的综合作用所致。我们报告了一例肾移植后发生的 AEN 病例。
一名 53 岁男性,患有高血压和终末期肾病,在肾移植后 14 天出现腹痛和单次呕血。
上消化道内镜检查显示食管中下段黏膜呈环形黑色。食管活检显示溃疡,免疫组化检查排除了病毒病因。
采用全胃肠外营养和质子泵抑制剂进行保守治疗。
患者未再出现呕血或腹痛,随访内镜检查显示黑色黏膜显著改善,变为红色易碎黏膜,伴有白色渗出物。
在该病例中,尽管没有低血压和感染等先前存在的因素,但在主要手术后血压正常的情况下发生了 AEN。对于出现腹痛、吞咽困难和呕血的实体器官移植患者,应考虑 AEN 的可能性。