与出生体重和心理健康相关的母体资源、孕期担忧及生物学因素
Maternal Resources, Pregnancy Concerns, and Biological Factors Associated to Birth Weight and Psychological Health.
作者信息
Ramiro-Cortijo David, de la Calle María, Gila-Díaz Andrea, Moreno-Jiménez Bernardo, Martin-Cabrejas Maria A, Arribas Silvia M, Garrosa Eva
机构信息
Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 2, 28029 Madrid, Spain.
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
出版信息
J Clin Med. 2021 Feb 10;10(4):695. doi: 10.3390/jcm10040695.
Cognitive maternal adaptation during pregnancy may influence biological variables, maternal psychological, and neonatal health. We hypothesized that pregnant women with numerous general resources and less negative emotions would have a better coping with a positive influence on neonatal birth weight and maternal psychological health. The study included 131 healthy pregnant women. A blood sample was obtained in the first trimester to assess biological variables (polyphenols, hematological and biochemical parameters). Psychological variables (negative affect, anxiety, optimism, resilience, family-work conflicts, pregnancy concerns, general resources, and life satisfaction) were evaluated at several time points along gestation, and birth weight was recorded. Hierarchical linear regression models were used to associate the above parameters with maternal psychological outcome at the end of gestation (depression, resilience, and optimism) and neonatal outcome (birth weight). Maternal depression was associated with leukocytes (β = 0.08 ± 0.03, -value = 0.003), cholesterol (β = 0.01 ± 0.002, -value = 0.026), and pregnancy concerns (β = 0.31 ± 0.09, -value = 0.001). Maternal resilience was associated with leukocytes (β = -0.14 ± 0.09, -value = 0.010) and life satisfaction (β = 0.82 ± 0.08, -value = 0.001), and maternal optimism was associated with polyphenol levels (β = 0.002 ± 0.001, -value = 0.018) and life satisfaction (β = 0.49 ± 0.04, -value = 0.001). Birth weight was associated with maternal resilience (β = 370.2 ± 97.0, -value = 0.001), red blood cells (β = 480.3 ± 144.4, -value = 0.001), and life satisfaction (β = 423.3 ± 32.6, -value = 0.001). We found associations between maternal psychological, blood variables, and birth weight and maternal depression. This study reveals the relevance of psychological health during pregnancy for maternal and neonatal outcome, and it emphasizes the need to consider it in preventive policies in the obstetric field.
孕期母亲的认知适应可能会影响生物学变量、母亲心理和新生儿健康。我们假设，拥有众多一般资源且负面情绪较少的孕妇能够更好地应对，这会对新生儿出生体重和母亲心理健康产生积极影响。该研究纳入了131名健康孕妇。在孕早期采集血样以评估生物学变量（多酚、血液学和生化参数）。在孕期的多个时间点评估心理变量（负面影响、焦虑、乐观、心理韧性、家庭 - 工作冲突、孕期担忧、一般资源和生活满意度），并记录出生体重。使用分层线性回归模型将上述参数与妊娠末期的母亲心理结果（抑郁、心理韧性和乐观）以及新生儿结果（出生体重）相关联。母亲抑郁与白细胞（β = 0.08 ± 0.03，P值 = 0.003）、胆固醇（β = 0.01 ± 0.002，P值 = 0.026）和孕期担忧（β = 0.31 ± 0.09，P值 = 0.001）相关。母亲心理韧性与白细胞（β = -0.14 ± 0.09，P值 = 0.010）和生活满意度（β = 0.82 ± 0.08，P值 = 0.001）相关，母亲乐观与多酚水平（β = 0.002 ± 0.001，P值 = 0.018）和生活满意度（β = 0.49 ± 0.04，P值 = 0.001）相关。出生体重与母亲心理韧性（β = 370.2 ± 97.0，P值 = 0.001）、红细胞（β = 480.3 ± 144.4，P值 = 0.001）和生活满意度（β = 423.3 ± 32.6，P值 = 0.001）相关。我们发现母亲心理、血液变量、出生体重与母亲抑郁之间存在关联。这项研究揭示了孕期心理健康对母亲和新生儿结局的相关性，并强调在产科领域的预防政策中需要考虑这一点。
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