• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过电喷雾法制造球形聚乙烯吡咯烷酮颗粒的操作参数测定

Determination of the Operational Parameters for the Manufacturing of Spherical PVP Particles via Electrospray.

作者信息

Narváez-Muñoz Christian, Ryzhakov Pavel, Pons-Prats Jordi

机构信息

Escola Tècnica Superior d'Enginyers de Camins, Canals i Ports, C/Jordi Girona 1, Campus Nord UPC, Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08034 Barcelona, Spain.

Centre Internacional de Mètodes Numérics en Enginyeria (CIMNE), C/Gran Capitán s/n, Campus Nord UPC, 08034 Barcelona, Spain.

出版信息

Polymers (Basel). 2021 Feb 10;13(4):529. doi: 10.3390/polym13040529.

DOI:10.3390/polym13040529
PMID:33578985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7916815/
Abstract

This work aims at bridging experimental and numerical approaches to determine the optimal operating parameters for the fabrication of well-shaped polyvinylpyrrolidone (PVP) particles via electrohydrodynamic atomization. Particular emphasis is given to the role of the PVP solution viscosity. Solutions of PVP at various concentrations dissolved in Dimethylformamide (DMF) were prepared and analyzed. Numerical simulation using a coupled electro-CFD model was used to determine the ranges of experimental flow rate and the voltage, ensuring that well-shaped spherical particles are produced. It was deduced that the optimal combination of the parameters (flow rate, voltage, and polymer concentration) can be well approximated by a scaling law. The established relationship allowed determination of a stability island that guarantees that the given polymer solution will form spherical particles. Analyzing morphology and sizes of the particles manufactured in the optimal parameters range, we show, among others, that the size of the PVP particles can be predicted as a function of the flow rate by a power scaling relationship.

摘要

这项工作旨在将实验方法和数值方法相结合，以确定通过电流体动力学雾化制备形状良好的聚乙烯吡咯烷酮（PVP）颗粒的最佳操作参数。特别强调了PVP溶液粘度的作用。制备并分析了溶解在二甲基甲酰胺（DMF）中的各种浓度的PVP溶液。使用耦合电-计算流体动力学（CFD）模型进行数值模拟，以确定实验流速和电压的范围，确保生成形状良好的球形颗粒。据推断，参数（流速、电压和聚合物浓度）的最佳组合可以通过比例定律很好地近似。所建立的关系允许确定一个稳定岛，该稳定岛保证给定的聚合物溶液将形成球形颗粒。通过分析在最佳参数范围内制造的颗粒的形态和尺寸，我们表明，除其他外，PVP颗粒的尺寸可以通过幂比例关系作为流速的函数进行预测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/fedb43c8880f/polymers-13-00529-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/eeddc0427253/polymers-13-00529-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/96959c6b1592/polymers-13-00529-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/5955adae145c/polymers-13-00529-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/06fed988db40/polymers-13-00529-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/3fd60697d670/polymers-13-00529-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/865583c6ca0a/polymers-13-00529-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/5b45c51f3291/polymers-13-00529-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/32f25f89de67/polymers-13-00529-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/517066193620/polymers-13-00529-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/6611079c3878/polymers-13-00529-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/fedb43c8880f/polymers-13-00529-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/eeddc0427253/polymers-13-00529-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/96959c6b1592/polymers-13-00529-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/5955adae145c/polymers-13-00529-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/06fed988db40/polymers-13-00529-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/3fd60697d670/polymers-13-00529-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/865583c6ca0a/polymers-13-00529-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/5b45c51f3291/polymers-13-00529-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/32f25f89de67/polymers-13-00529-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/517066193620/polymers-13-00529-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/6611079c3878/polymers-13-00529-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b664/7916815/fedb43c8880f/polymers-13-00529-g013.jpg

相似文献

1
Determination of the Operational Parameters for the Manufacturing of Spherical PVP Particles via Electrospray.通过电喷雾法制造球形聚乙烯吡咯烷酮颗粒的操作参数测定
Polymers (Basel). 2021 Feb 10;13(4):529. doi: 10.3390/polym13040529.
2
Stable increased formulation atomization using a multi-tip nozzle device.采用多尖端喷嘴装置实现稳定的增稠制剂雾化。
Drug Deliv Transl Res. 2018 Dec;8(6):1815-1827. doi: 10.1007/s13346-018-0518-4.
3
Electrohydrodynamic Processing of PVP-Doped Kraft Lignin Micro- and Nano-Structures and Application of Electrospun Nanofiber Templates to Produce Oleogels.聚乙烯吡咯烷酮掺杂硫酸盐木质素微纳结构的电流体动力学加工及电纺纳米纤维模板在制备油凝胶中的应用
Polymers (Basel). 2021 Jul 3;13(13):2206. doi: 10.3390/polym13132206.
4
Supercritical Assisted Electrospray: An Improved Micronization Process.超临界辅助电喷雾：一种改进的微粉化工艺。
Polymers (Basel). 2019 Feb 2;11(2):244. doi: 10.3390/polym11020244.
5
A Facile Method for Preparation of Polymer Particles Having a "Cylindrical" Shape.一种制备“圆柱形”聚合物颗粒的简便方法。
Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9936-9940. doi: 10.1002/anie.201805700. Epub 2018 Jun 29.
6
Alignment of One-Dimensional SnO2 Lines by Electrohydrodynamic Jet Printing.通过电流体动力学喷射印刷实现一维SnO₂线的排列。
J Nanosci Nanotechnol. 2016 Feb;16(2):1818-21. doi: 10.1166/jnn.2016.11962.
7
Control of shape and size of polymer nanoparticles aggregates in a single-step microcontinuous flow process: a case of flower and spherical shapes.在单步微连续流过程中控制聚合物纳米颗粒聚集体的形状和尺寸：以花状和球形为例。
Langmuir. 2014 Oct 21;30(41):12180-9. doi: 10.1021/la502896s. Epub 2014 Oct 7.
8
Ultrasound-based treatment approaches for intrinsic viscosity reduction of polyvinyl pyrrolidone (PVP).基于超声的降低聚乙烯吡咯烷酮（PVP）特性粘度的处理方法。
Ultrason Sonochem. 2014 May;21(3):1108-16. doi: 10.1016/j.ultsonch.2013.12.013. Epub 2013 Dec 21.
9
Electro-hydrodynamic atomization of drug solutions for inhalation purposes.用于吸入目的的药物溶液的电液动力雾化
J Appl Physiol (1985). 2001 Dec;91(6):2735-41. doi: 10.1152/jappl.2001.91.6.2735.
10
Investigating the particle to fibre transition threshold during electrohydrodynamic atomization of a polymer solution.研究聚合物溶液电液动力雾化过程中的颗粒到纤维转变阈值。
Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:240-50. doi: 10.1016/j.msec.2016.03.076. Epub 2016 Mar 24.

引用本文的文献

1
Polyacrylonitrile/Silver Nanoparticles Composite for Catalytic Dye Reduction and Real-Time Monitoring.用于催化染料还原及实时监测的聚丙烯腈/银纳米颗粒复合材料
Polymers (Basel). 2025 Jun 26;17(13):1762. doi: 10.3390/polym17131762.
2
Fabrication, Physical-Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications.用于伤口愈合的载视黄醇聚乙烯醇电纺纤维垫的制备、物理化学及生物学表征
Polymers (Basel). 2023 Jun 16;15(12):2705. doi: 10.3390/polym15122705.

本文引用的文献

1
Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters.通过电喷雾制备聚合物微粒：实验参数的影响
J Funct Biomater. 2020 Jan 15;11(1):4. doi: 10.3390/jfb11010004.
2
Advances in particle shape engineering for improved drug delivery.颗粒形状工程学在改善药物传递方面的进展。
Drug Discov Today. 2019 Feb;24(2):575-583. doi: 10.1016/j.drudis.2018.10.006. Epub 2018 Oct 17.
3
Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly.
聚合诱导自组装法制备的纳米粒子的尺寸和形状对其生物分布的影响。
Biomacromolecules. 2017 Dec 11;18(12):3963-3970. doi: 10.1021/acs.biomac.7b00995. Epub 2017 Sep 29.
4
Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials.电流体动力学雾化：生产和加工微/纳米颗粒材料的二十年努力。
Chem Eng Sci. 2015 Mar 24;125:32-57. doi: 10.1016/j.ces.2014.08.061.
5
Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles.塑造癌症纳米医学：颗粒形状对纳米颗粒体内旅程的影响。
Nanomedicine (Lond). 2014 Jan;9(1):121-34. doi: 10.2217/nnm.13.191.
6
Coaxial electrohydrodynamic atomization process for production of polymeric composite microspheres.用于生产聚合物复合微球的同轴电流体动力学雾化工艺
Chem Eng Sci. 2013 Dec 18;104. doi: 10.1016/j.ces.2013.09.020.
7
Numerical simulation of electrospray in the cone-jet mode.锥形射流模式下电喷雾的数值模拟。
Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Aug;86(2 Pt 2):026305. doi: 10.1103/PhysRevE.86.026305. Epub 2012 Aug 8.
8
Controlling the morphology of electrospray-generated PLGA microparticles for drug delivery.控制电喷雾生成的 PLGA 微球用于药物输送的形态。
J Colloid Interface Sci. 2010 Mar 1;343(1):125-33. doi: 10.1016/j.jcis.2009.10.002. Epub 2009 Oct 24.