Profile and antimicrobial resistance to newly available drugs of urinary tract pathogens among Malagasy pregnant women.

Urinary tract infections are caused by growth of microorganisms anywhere in the urinary tract and pregnant women are particularly susceptible to it. Collection of baseline information regarding urinary tract bacterial profile and their antimicrobial susceptibility in pregnant women are important for treatment purposes. In order to determine the distribution of community-acquired urinary tract pathogens and estimate their susceptibility patterns to antimicrobial agents currently available in Antananarivo (Madagascar), we conducted a cross sectional preliminary survey (four months) on bacteria isolated from urine of pregnant women attending antenatal care clinic, Ambohimiandra Hospital Center. Fifty pathogens were isolated of which 21 (42%) were Gram-negative bacilli and 29 (58%) Gram-positive cocci. The most commonly isolated pathogen was Coagulase Negative Staphylococci (13 strains) for Gram-positive cocci and Escherichia coli (6 strains) for Gram-negative bacilli. Thirty three percent of Gram-negative bacilli were resistant to 3GC. One Klebsiella pneumoniae strain was found to be resistant to imipenem and one Group B Streptococci strain was vancomycin resistant. This development of resistance to newly available antimicrobial and the increase proportion of Gram-positive cocci strains imply that a drastic antimicrobial resistance surveillance need to be carried out to ensure appropriate empirical treatment.