Abdallah R M, Starkey J R, Meadows G G
College of Pharmacy and the Pharmacology/Toxicology Program, Washington State University, Pullman 99164-6510.
Res Commun Chem Pathol Pharmacol. 1988 Feb;59(2):245-58.
The toxicity of chronic alcohol intake on natural killer (NK) cell activity of spleen cells from well-nourished, female C57BL/6 mice was studied in a 4-hour cytolytic chromium-release assay against YAC-1 lymphoma cells. Mice were fed a nutritionally complete crystalline amino acid diet and received 20% w/v alcohol solution for 12 weeks. Ad libitum and pair-fed control mice were given diet and either an isocaloric glucose solution or water. Decreased NK cell activity was observed in alcohol-consuming mice relative to all other control groups. NK cell activity was moderately decreased by feeding mice a high glucose diet, but more severely lowered in pair-fed groups compared to ad libitum control groups.
在针对YAC-1淋巴瘤细胞的4小时细胞溶解铬释放试验中，研究了长期摄入酒精对营养良好的雌性C57BL/6小鼠脾细胞自然杀伤（NK）细胞活性的毒性。给小鼠喂食营养完全的结晶氨基酸饮食，并给予20% w/v酒精溶液，持续12周。随意进食和配对喂养的对照小鼠给予饮食以及等热量的葡萄糖溶液或水。与所有其他对照组相比，观察到饮酒小鼠的NK细胞活性降低。给小鼠喂食高糖饮食会使NK细胞活性适度降低，但与随意进食对照组相比，配对喂养组的NK细胞活性降低更为严重。
