• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome.

作者信息

Winter Greta, Kirschner-Schwabe Renate, Groeneveld-Krentz Stefanie, Escherich Gabriele, Möricke Anja, von Stackelberg Arend, Stanulla Martin, Bailey Simon, Richter Lisa, Steinemann Doris, Ripperger Tim, Escudero Adela, Farah Roula, Lohi Olli, Wadt Karin, Jongmans Marjolijn, van Engelen Nienke, Eckert Cornelia, Kratz Christian Peter

机构信息

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

Department of Pediatric Oncology and Hematology, Charité-University Medical Center Berlin, Berlin, Germany.

出版信息

Leukemia. 2021 May;35(5):1475-1479. doi: 10.1038/s41375-021-01163-y. Epub 2021 Feb 12.

DOI:10.1038/s41375-021-01163-y
PMID:33580201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8102191/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b128/8102191/174200b876b4/41375_2021_1163_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b128/8102191/174200b876b4/41375_2021_1163_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b128/8102191/174200b876b4/41375_2021_1163_Fig1_HTML.jpg

相似文献

1
Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome.急性淋巴细胞白血病合并李-弗劳梅尼综合征患儿的临床及遗传学特征
Leukemia. 2021 May;35(5):1475-1479. doi: 10.1038/s41375-021-01163-y. Epub 2021 Feb 12.
2
Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features.在李-弗劳梅尼综合征背景下发生的胶质瘤可分为两个具有不同临床病理特征的分子亚组。
Acta Neuropathol. 2020 May;139(5):953-957. doi: 10.1007/s00401-020-02144-8. Epub 2020 Mar 10.
3
[Radiation-induced intracranial osteosarcoma after radiation for acute lymphocytic leukemia associated with Li-Fraumeni syndrome].[与李-弗劳梅尼综合征相关的急性淋巴细胞白血病放疗后发生的放射性颅内骨肉瘤]
No Shinkei Geka. 2013 Jun;41(6):499-505.
4
Identification of a novel p53 in-frame deletion in a Li-Fraumeni-like family.在一个李-佛美尼综合征样家族中鉴定出一种新型的p53框内缺失。
Pediatr Blood Cancer. 2008 Apr;50(4):914-6. doi: 10.1002/pbc.21247.
5
Li-Fraumeni and Li-Fraumeni-like syndrome among children diagnosed with pediatric cancer in Southern Brazil.巴西南部儿童癌症患者中李-佛美尼综合征和李-佛美尼样综合征。
Cancer. 2013 Dec 15;119(24):4341-9. doi: 10.1002/cncr.28346. Epub 2013 Oct 7.
6
[Li-Fraumeni syndrome].[李-弗劳梅尼综合征]
Bull Cancer. 1997 Jul;84(7):735-40.
7
Familial gastric cancer and Li-Fraumeni syndrome.家族性胃癌与 Li-Fraumeni 综合征。
Eur J Cancer Care (Engl). 2010 May;19(3):377-81. doi: 10.1111/j.1365-2354.2008.01066.x. Epub 2009 Aug 7.
8
Should Genetic Testing be Offered for Children? The Perspectives of Adolescents and Emerging Adults in Families with Li-Fraumeni Syndrome.是否应该为儿童提供基因检测？李-弗劳梅尼综合征家庭中青少年和刚成年者的观点。
J Genet Couns. 2017 Oct;26(5):1106-1115. doi: 10.1007/s10897-017-0091-x. Epub 2017 Mar 16.
9
Breast cancer patients suggestive of Li-Fraumeni syndrome: mutational spectrum, candidate genes, and unexplained heredity.疑似李-佛美尼综合征的乳腺癌患者：突变谱、候选基因和无法解释的遗传。
Breast Cancer Res. 2018 Aug 7;20(1):87. doi: 10.1186/s13058-018-1011-1.
10
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病中的遗传性和获得性p53基因突变
J Clin Invest. 1992 Feb;89(2):640-7. doi: 10.1172/JCI115630.

引用本文的文献

1
Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study.儿童癌症幸存者中的胚系致病性/可能致病性突变及后续肿瘤：儿童肿瘤学组ALTE03N1研究报告
J Clin Oncol. 2025 Aug 19:JCO2500542. doi: 10.1200/JCO-25-00542.
2
A Comprehensive Review of Somatic and Germline Biomarkers Associated with Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: From Biological Significance to Precision Medicine Opportunities.与儿童B细胞前体急性淋巴细胞白血病相关的体细胞和种系生物标志物的综合综述：从生物学意义到精准医学机遇
Biomedicines. 2025 Jul 2;13(7):1626. doi: 10.3390/biomedicines13071626.
3
Subclonal TP53 and KRAS variants combined with poor treatment response identify ultrahigh-risk pediatric patients with T-ALL.
亚克隆性TP53和KRAS变异与治疗反应不佳相结合可识别出T细胞急性淋巴细胞白血病的超高风险儿科患者。
Blood Adv. 2025 Mar 25;9(6):1267-1279. doi: 10.1182/bloodadvances.2024014209.
4
Re-envisioning genetic predisposition to childhood and adolescent cancers.重新审视儿童和青少年癌症的遗传易感性。
Nat Rev Cancer. 2025 Feb;25(2):109-128. doi: 10.1038/s41568-024-00775-7. Epub 2024 Dec 3.
5
Current insights and future directions of Li-Fraumeni syndrome.李-弗劳梅尼综合征的当前见解与未来方向
Discov Oncol. 2024 Oct 15;15(1):561. doi: 10.1007/s12672-024-01435-w.
6
Germline Variants and Characteristic Features of Hereditary Hematological Malignancy Syndrome.胚系变异与遗传性血液恶性肿瘤综合征的特征表现。
Int J Mol Sci. 2024 Jan 4;25(1):652. doi: 10.3390/ijms25010652.
7
Medical students' knowledge on cancer predisposition syndromes and attitude toward eHealth.医学生对癌症易感性综合征的认识及对电子健康的态度。
Arch Gynecol Obstet. 2024 Apr;309(4):1535-1541. doi: 10.1007/s00404-023-07266-4. Epub 2023 Nov 7.
8
The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP).复发性急性淋巴细胞白血病网络（ReALLNet）：西班牙儿科血液学与肿瘤学学会（SEHOP）的一个多学科项目。
Front Pediatr. 2023 Sep 20;11:1269560. doi: 10.3389/fped.2023.1269560. eCollection 2023.
9
Identifying health research in the era of COVID-19: A scoping review.识别新冠疫情时代的健康研究：一项范围综述
SAGE Open Med. 2023 Jun 8;11:20503121231180030. doi: 10.1177/20503121231180030. eCollection 2023.
10
Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.儿童 B 细胞急性淋巴细胞白血病非整倍体概述。
Int J Mol Sci. 2023 May 15;24(10):8764. doi: 10.3390/ijms24108764.