Department of Biological Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, NY, USA.
Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Handb Exp Pharmacol. 2022;275:33-52. doi: 10.1007/164_2021_442.
All organisms have the ability to detect chemicals in the environment, which likely evolved out of organisms' needs to detect food sources and avoid potentially harmful compounds. The taste system detects chemicals and is used to determine whether potential food items will be ingested or rejected. The sense of taste detects five known taste qualities: bitter, sweet, salty, sour, and umami, which is the detection of amino acids, specifically glutamate. These different taste qualities encompass a wide variety of chemicals that differ in their structure and as a result, the peripheral taste utilizes numerous and diverse mechanisms to detect these stimuli. In this chapter, we will summarize what is currently known about the signaling mechanisms used by taste cells to transduce stimulus signals.
所有生物体都有能力检测环境中的化学物质,这可能是生物体进化出的一种能力,以便于它们能够探测到食物来源并避免潜在的有害化合物。味觉系统可以检测化学物质,并用于判断潜在的食物是否被摄入或被拒绝。味觉可以感知五种已知的味道:苦、甜、咸、酸和鲜味,鲜味是对氨基酸的检测,特别是谷氨酸。这些不同的味道涵盖了结构各异的各种化学物质,因此,外周味觉利用多种不同的机制来检测这些刺激。在本章中,我们将总结目前已知的味觉细胞用于转导刺激信号的信号机制。