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在 ICU 入住时谵妄或机械通气患者的药物治疗史的准确性和安全性。

Accuracy and safety of medication histories obtained at the time of intensive care unit admission of delirious or mechanically ventilated patients.

机构信息

Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC, USA.

出版信息

Am J Health Syst Pharm. 2021 Mar 31;78(8):736-742. doi: 10.1093/ajhp/zxab040.

DOI:10.1093/ajhp/zxab040
PMID:33580666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7953979/
Abstract

PURPOSE

Obtaining an accurate medication history from patients on hospital admission is a priority in pharmacy practice. Timely and accurate histories are imperative as they may help determine the etiology of illness and prevent medication errors. We conducted a quality improvement project to assess the accuracy of alternate-source medication histories obtained for critically ill patients who were delirious or mechanically ventilated at the time of intensive care unit admission.

METHODS

Included patients were 18 years of age or older, admitted to the medical intensive care unit from August 2017 through January 2018, and had a medication history obtained from a family member or outpatient pharmacy due to active delirium or mechanical ventilation. Patients were directly interviewed after resolution of delirium or extubation. Discrepancies between the initial and follow-up histories were documented and categorized using the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) Index for Categorizing Medication Errors.

RESULTS

Forty patients were included. One hundred four discrepancies were documented, with a median of 2 discrepancies per patient. The most common types of discrepancies were addition (51.9%), followed by omission (24.0%). NCC MERP index category A (51%) was the most common error classification identified.

CONCLUSION

Discrepancies between initial and follow-up medication histories occurred at a frequent rate in delirious or mechanically ventilated patients; however, these discrepancies tended to be of low risk severity.

摘要

目的

在患者入院时获取准确的用药史是药学实践的重中之重。及时、准确的用药史至关重要,因为它有助于确定疾病的病因并预防用药错误。我们开展了一项质量改进项目,以评估在 ICU 入院时处于谵妄或机械通气状态的危重症患者的替代来源用药史的准确性。

方法

纳入标准为 18 岁及以上,因活跃性谵妄或机械通气而从 2017 年 8 月至 2018 年 1 月从内科 ICU 入院,且用药史是从家属或门诊药房获得的患者。在患者谵妄缓解或拔管后,对其进行直接访谈。记录初始和随访用药史之间的差异,并使用国家协调委员会药物错误报告和预防(NCC MERP)索引对药物错误进行分类。

结果

共纳入 40 例患者。共记录了 104 个差异,中位数为每个患者 2 个差异。最常见的差异类型是添加(51.9%),其次是遗漏(24.0%)。最常见的错误分类是 NCC MERP 索引 A 类(51%)。

结论

在谵妄或机械通气患者中,初始和随访用药史之间存在频繁的差异,但这些差异往往严重程度较低。

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本文引用的文献

1
Medication Histories in Critically Ill Patients Completed by Pharmacy Personnel.危重症患者的药物治疗史由药剂人员完成。
Ann Pharmacother. 2019 Jun;53(6):596-602. doi: 10.1177/1060028018825483. Epub 2019 Jan 17.
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The effect of a medication reconciliation program in two intensive care units in the Netherlands: a prospective intervention study with a before and after design.荷兰两个重症监护病房用药重整计划的效果:一项采用前后设计的前瞻性干预研究。
Ann Intensive Care. 2018 Feb 7;8(1):19. doi: 10.1186/s13613-018-0361-2.
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ASHP statement on the pharmacist's role in medication reconciliation.美国卫生系统药师协会关于药师在用药核对中作用的声明。
Am J Health Syst Pharm. 2013 Mar 1;70(5):453-6. doi: 10.2146/sp120009.
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The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies.用于重症监护病房谵妄诊断的重症监护病房意识模糊评估方法(CAM-ICU)和重症监护谵妄筛查清单(ICDSC):临床研究的系统评价和荟萃分析
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Reliability evaluation of the adapted national coordinating council medication error reporting and prevention (NCC MERP) index.改编后的国家协调委员会用药错误报告与预防(NCC MERP)指数的可靠性评估。
Pharmacoepidemiol Drug Saf. 2007 Sep;16(9):1006-13. doi: 10.1002/pds.1423.
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Unintended medication discrepancies at the time of hospital admission.入院时意外的用药差异。
Arch Intern Med. 2005 Feb 28;165(4):424-9. doi: 10.1001/archinte.165.4.424.
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The completeness of medication histories in hospital medical records of patients admitted to general internal medicine wards.综合内科病房收治患者的医院病历中用药史的完整性。
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