Department of Dermatology, Marmara University, School of Medicine, Istanbul, Turkey.
Department of Medical Biology and Genetics, Marmara University, School of Medicine, Istanbul, Turkey.
Dermatol Ther. 2021 Mar;34(2):e14872. doi: 10.1111/dth.14872. Epub 2021 Feb 23.
Depression is a comorbidity of psoriasis. Suppression of neurotrophins has been proposed to cause depression. Peripheral brain-derived neurotrophic factor (BDNF) and its precursor, pro-BDNF have been shown to be altered in depression. To compare serum pro-BDNF and BDNF levels, depression, anxiety, and quality of life (QoL) in psoriasis patients, diseased, and healthy controls, to assess impact of 12-week antipsoriatic treatment on abovementioned markers. At baseline, all groups completed Beck Depression Inventory (BDI), Spielberger State-Trait Anxiety Inventory-II (STAI-II) and DLQI; serum BDNF, proBDNF levels were measured. These were repeated after 3-months of treatment in psoriasis patients. Depression and anxiety were significantly higher, QoL was poorer in psoriasis. ProBDNF and proBDNF/BDNF ratios were not different among groups at baseline but significantly decreased after treatment in psoriasis. Depression and QoL improved significantly, BDNF and anxiety scores did not change. Altered pro-BDNF and proBDNF/BDNF ratios may have a role in depression pathogenesis in psoriasis. Antipsoriatic treatment causes improvement in depression, QoL, and reduction of proBDNF and proBDNF/BDNF ratios. Effective disease control may reverse dysregulated neurotrophin pathways and its consequences like depression.
抑郁是银屑病的一种合并症。有人提出，神经营养因子的抑制作用可能导致抑郁。已经表明，外周脑源性神经营养因子 (BDNF) 和其前体，pro-BDNF 在抑郁中发生改变。为了比较银屑病患者、患者和健康对照者的血清 pro-BDNF 和 BDNF 水平、抑郁、焦虑和生活质量 (QoL)，评估 12 周抗银屑病治疗对上述标志物的影响。在基线时，所有组都完成贝克抑郁量表 (BDI)、斯皮尔伯格状态-特质焦虑量表-II (STAI-II) 和 DLQI；测量血清 BDNF、proBDNF 水平。在银屑病患者治疗 3 个月后重复这些。银屑病患者的抑郁和焦虑明显更高，QoL 更差。在基线时各组之间的 proBDNF 和 proBDNF/BDNF 比值没有差异，但在银屑病治疗后显著降低。抑郁和 QoL 显著改善，BDNF 和焦虑评分没有变化。改变的 pro-BDNF 和 proBDNF/BDNF 比值可能在银屑病的抑郁发病机制中起作用。抗银屑病治疗可改善抑郁、QoL，并降低 proBDNF 和 proBDNF/BDNF 比值。有效的疾病控制可能会逆转失调的神经营养因子途径及其后果，如抑郁。
